Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 7/20 | 0.36 |
| ▸ | MLYCD | O95822 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.33 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 2/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4033763 | 0.84 | TRPM8 (0.36) | TRPM8MRGPRX4MLYCDALDH1A1LMNA | |
| SCHEMBL4026691 | 0.78 | CES2 (0.55) | TRPM8MLYCDALDH1A1KAT6ARIPK1 | |
| SCHEMBL4027267 | 0.76 | KAT6A (0.41) | TRPM8MLYCDALDH1A1KAT6ALPAR5 | |
| SCHEMBL2285021 | 0.75 | HPGD (0.40) | TRPM8MLYCDALDH1A1LMNAKAT6A | |
| SCHEMBL17064947 | 0.75 | ALDH1A1 (0.43) | TRPM8MLYCDALDH1A1LPAR5BCHE | |
| SCHEMBL4804041 | 0.75 | KAT6A (0.47) | ALDH1A1LMNAKAT6ALPAR5 | |
| SCHEMBL3688705 | 0.75 | CYP11B1 (0.48) | TRPM8MLYCDKAT6ATSHRCES2 | |
| SCHEMBL13806872 | 0.74 | ALDH1A1 (0.42) | ALDH1A1LMNATSHR | |
| SCHEMBL4610471 | 0.73 | LMNA (0.46) | TRPM8ALDH1A1LMNATSHRBCHE | |
| SCHEMBL1125455 | 0.73 | HDAC8 (0.49) | TRPM8MLYCDLMNAKAT6A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116655625-A | Compounds as SOS1 inhibitors and uses thereof | 南京圣和药业股份有限公司 | 2023-08-29 | — | — | CN | disclosed |