Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.52 |
| ▸ | NPFFR1 | Q9GZQ6 | 2/20 | 0.47 |
| ▸ | NPFFR2 | Q9Y5X5 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29941882 | 0.86 | ALDH1A1 (0.70) | LMNAALDH1A1POLBSLC9A1GAA | |
| SCHEMBL376111 | 0.86 | ALDH1A1 (0.70) | LMNAALDH1A1POLBSLC9A1GAA | |
| SCHEMBL4943598 | 0.82 | SMN1; SMN2 (0.76) | LMNAALDH1A1POLBSLC9A1GAA | |
| SCHEMBL29352634 | 0.79 | SLC9A1 (0.61) | ALDH1A1SLC9A1GAASMN1; SMN2MAPT | |
| SCHEMBL8348740 | 0.79 | SLC9A1 (0.61) | ALDH1A1SLC9A1GAASMN1; SMN2MAPT | |
| SCHEMBL19657077 | 0.78 | SLC9A1 (0.64) | LMNAALDH1A1POLBSLC9A1GAA | |
| SCHEMBL28269605 | 0.77 | ALDH1A1 (0.75) | LMNAALDH1A1SLC9A1GAASMN1; SMN2 | |
| SCHEMBL19354982 | 0.75 | LMNA (0.78) | LMNAALDH1A1POLBSLC9A1GAA | |
| SCHEMBL3613648 | 0.74 | LMNA (0.55) | LMNAALDH1A1POLBSLC9A1GAA | |
| SCHEMBL31462930 | 0.73 | ALDH1A1 (0.42) | LMNAALDH1A1HPGDNPSR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11634400-B2 | Micheliolide derivatives, methods for their preparation and their use as anticancer and antiinflammatory agents | UNIVERSITY OF ROCHESTER (US) | 2023-04-25 | — | — | US | disclosed |
| US-20200277270-A1 | MICHELIOLIDE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS ANTICANCER AND ANTIINFLAMMATORY AGENTS | UNIVERSITY OF ROCHESTER | 2020-09-03 | — | — | US | disclosed |
| WO-2019040335-A1 | MICHELIOLIDE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS ANTICANCER AND ANTIINFLAMMATORY AGENTS | UNIVERSITY OF ROCHESTER (US) | 2019-02-28 | — | — | WO | disclosed |
| US-20160115508-A1 | PARTHENOLIDE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS ANTICANCER AGENTS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2016-04-28 | — | — | US | disclosed |
| EP-3003317-A2 | PARTHENOLIDE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS ANTICANCER AGENTS | University Of Rochester (US) | 2016-04-13 | — | — | EP | disclosed |
| WO-2014197591-A2 | PARTHENOLIDE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS ANTICANCER AGENTS | UNIVERSITY OF ROCHESTER (US) | 2014-12-11 | — | — | WO | disclosed |
| US-8541406-B2 | Thiadiazole derivatives for the treatment of neurodegenerative diseases | NV REMYND (BE) | 2013-09-24 | — | — | US | disclosed |
| US-20100261707-A9 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2010-10-14 | — | — | US | disclosed |
| US-20090233911-A2 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-09-17 | — | — | US | disclosed |
| US-20090054410-A1 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11634400-B2 | Micheliolide derivatives, methods for their preparation and their use as anticancer and antiinflammatory agents | TNF, C9, CYP51A1 | LMNA 955/4885ALDH1A1 1456/4885POLB 4198/4885 |
| US-20090233911-A2 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SNCA, HTT, PARK7 | LMNA 1113/4885ALDH1A1 1930/4885POLB 3933/4885 |
| US-20100261707-A9 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SNCA, HTT, PARK7 | LMNA 1113/4885ALDH1A1 1930/4885POLB 3933/4885 |
| US-20200277270-A1 | MICHELIOLIDE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS ANTICANCER AND ANTIINFLAMMATORY AGENTS | TNF, C9, CYP51A1 | LMNA 955/4885ALDH1A1 1456/4885POLB 4198/4885 |
| US-20090054410-A1 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SNCA, HTT, PARK7 | LMNA 1113/4885ALDH1A1 1930/4885POLB 3933/4885 |
| US-20160115508-A1 | PARTHENOLIDE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS ANTICANCER AGENTS | CYP3A43, POR, CYP3A4 | LMNA 1744/4885ALDH1A1 425/4885POLB 1165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.