Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6633552 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2KMT2ATSHRMAPTMEN1 | |
| SCHEMBL6635707 | 0.81 | SMN1; SMN2 (0.69) | SMN1; SMN2KMT2ATSHRMAPTMEN1 | |
| SCHEMBL13219529 | 0.80 | KCNMA1 (0.68) | SMN1; SMN2KMT2ATSHRMAPTRAB9A | |
| SCHEMBL6638142 | 0.80 | ATM (0.77) | SMN1; SMN2KMT2ATSHRMAPTMEN1 | |
| SCHEMBL1520253 | 0.80 | KMT2A (0.67) | SMN1; SMN2KMT2ATSHRMAPTMEN1 | |
| SCHEMBL30117825 | 0.80 | RAB9A (0.74) | SMN1; SMN2KMT2ATSHRMAPTMEN1 | |
| SCHEMBL6632751 | 0.80 | RAB9A (0.74) | SMN1; SMN2KMT2ATSHRMAPTMEN1 | |
| SCHEMBL28634421 | 0.80 | SMN1; SMN2 (0.66) | SMN1; SMN2KMT2ATSHRMAPTMEN1 | |
| SCHEMBL15528812 | 0.79 | MAPK1 (0.71) | SMN1; SMN2KMT2ATSHRMAPTMEN1 | |
| SCHEMBL13212283 | 0.79 | KMT2A (0.65) | SMN1; SMN2KMT2ATSHRMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12227493-B2 | Methods of inhibiting kinases | INSILICO MEDICINE IP LIMITED (HK) | 2025-02-18 | — | — | US | disclosed |
| US-20240092765-A1 | METHODS OF INHIBITING KINASES | INSILICO MEDICINE IP LIMITED (HK) | 2024-03-21 | — | — | US | disclosed |
| US-11739078-B2 | Methods of inhibiting kinases | INSILICO MEDICINE IP LIMITED (HK) | 2023-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240092765-A1 | METHODS OF INHIBITING KINASES | TNK1, TNNI3K, MAP4K2 | SMN1; SMN2 4000/4885KMT2A 2156/4885TSHR 1395/4885 |
| US-12227493-B2 | Methods of inhibiting kinases | TNK1, TNNI3K, MAP4K2 | SMN1; SMN2 4000/4885KMT2A 2156/4885TSHR 1395/4885 |
| US-11739078-B2 | Methods of inhibiting kinases | TNK1, TNNI3K, MAP4K2 | SMN1; SMN2 3992/4885KMT2A 2169/4885TSHR 1405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.