Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 5/20 | 0.66 |
| ▸ | NPC1 | O15118 | 2/20 | 0.66 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14096453 | 0.85 | KMT2A (0.76) | SMN1; SMN2KMT2AGAANPC1MAPT | |
| SCHEMBL6632751 | 0.81 | RAB9A (0.74) | SMN1; SMN2KMT2ANPC1KCNMA1TP53 | |
| SCHEMBL6633552 | 0.81 | SMN1; SMN2 (1.00) | SMN1; SMN2KMT2AGAANPC1TSHR | |
| SCHEMBL30117825 | 0.81 | RAB9A (0.74) | SMN1; SMN2KMT2ANPC1KCNMA1TP53 | |
| SCHEMBL1520253 | 0.81 | KMT2A (0.67) | SMN1; SMN2KMT2AGAANPC1TP53 | |
| SCHEMBL6638142 | 0.81 | ATM (0.77) | SMN1; SMN2KMT2AGAATSHRMAPT | |
| SCHEMBL30587183 | 0.81 | SMN1; SMN2 (1.00) | SMN1; SMN2KMT2AGAANPC1TSHR | |
| SCHEMBL15528812 | 0.80 | MAPK1 (0.71) | SMN1; SMN2KMT2AGAANPC1TSHR | |
| SCHEMBL13212283 | 0.80 | KMT2A (0.65) | SMN1; SMN2KMT2AGAANPC1TP53 | |
| SCHEMBL13219539 | 0.80 | KCNMA1 (0.79) | SMN1; SMN2KMT2AGAANPC1KCNMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1442041-A1 | AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-08-04 | — | — | EP | claimed |
| WO-2003040147-A1 | AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE__________________________________________________________________________________________________________________________ | PHARMACIA & UPJOHN COMPANY (US) | 2003-05-15 | — | — | WO | claimed |
| EP-1442041-A1 | AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003040147-A1 | AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE__________________________________________________________________________________________________________________________ | PHARMACIA & UPJOHN COMPANY (US) | 2003-05-15 | — | — | WO | disclosed |
| EP-0443045-B1 | HEAT-SENSITIVE SUBLIMATION TRANSFER CYAN DYE AND TRANSFER SHEET | MITSUI TOATSU CHEMICALS (JP) | 1995-01-11 | — | — | EP | disclosed |
| US-5183474-A | HEAT-SENSITIVE SUBLIMATION TRANSFER CYAN DYE AND TRANSFER SHEET | MITSUI TOATSU CHEMICALS INC. (JP) | 1993-02-02 | — | — | US | disclosed |
| EP-0443045-A1 | HEAT-SENSITIVE SUBLIMATION TRANSFER CYAN DYE AND TRANSFER SHEET | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1991-08-28 | — | — | EP | disclosed |