Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30587183 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2KMT2ATSHRMAPTMEN1 | |
| SCHEMBL6635707 | 0.81 | SMN1; SMN2 (0.69) | SMN1; SMN2KMT2ATSHRMAPTMEN1 | |
| SCHEMBL13219529 | 0.80 | KCNMA1 (0.68) | SMN1; SMN2KMT2ATSHRMAPTRAB9A | |
| SCHEMBL6638142 | 0.80 | ATM (0.77) | SMN1; SMN2KMT2ATSHRMAPTMEN1 | |
| SCHEMBL1520253 | 0.80 | KMT2A (0.67) | SMN1; SMN2KMT2ATSHRMAPTMEN1 | |
| SCHEMBL30117825 | 0.80 | RAB9A (0.74) | SMN1; SMN2KMT2ATSHRMAPTMEN1 | |
| SCHEMBL6632751 | 0.80 | RAB9A (0.74) | SMN1; SMN2KMT2ATSHRMAPTMEN1 | |
| SCHEMBL28634421 | 0.80 | SMN1; SMN2 (0.66) | SMN1; SMN2KMT2ATSHRMAPTMEN1 | |
| SCHEMBL15528812 | 0.79 | MAPK1 (0.71) | SMN1; SMN2KMT2ATSHRMAPTMEN1 | |
| SCHEMBL13212283 | 0.79 | KMT2A (0.65) | SMN1; SMN2KMT2ATSHRMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1442041-A1 | AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-08-04 | — | — | EP | claimed |
| WO-2003040147-A1 | AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE__________________________________________________________________________________________________________________________ | PHARMACIA & UPJOHN COMPANY (US) | 2003-05-15 | — | — | WO | claimed |
| EP-1442041-A1 | AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003040147-A1 | AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE__________________________________________________________________________________________________________________________ | PHARMACIA & UPJOHN COMPANY (US) | 2003-05-15 | — | — | WO | disclosed |