Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 3/20 | 0.33 |
| ▸ | BIRC2 | Q13490 | 3/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | PRF1 | P14222 | 1/20 | 0.30 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19641430 | 0.88 | SIRT6 (0.40) | XIAPBIRC2LCKPRF1SIRT6 | |
| SCHEMBL30036680 | 0.88 | SIRT6 (0.40) | XIAPBIRC2LCKPRF1SIRT6 | |
| SCHEMBL16506549 | 0.79 | KDM4E (0.43) | — | |
| SCHEMBL16516076 | 0.77 | XIAP (0.34) | XIAPBIRC2SIRT6 | |
| SCHEMBL16521060 | 0.77 | XIAP (0.34) | XIAPBIRC2 | |
| SCHEMBL18754398 | 0.73 | RIPK1 (0.34) | XIAPBIRC2 | |
| SCHEMBL3324562 | 0.70 | GABRA1 (0.54) | — | |
| SCHEMBL29875709 | 0.68 | LCK (0.35) | LCKPRF1SIRT6 | |
| SCHEMBL16418923 | 0.66 | NOS3 (0.54) | — | |
| SCHEMBL18248727 | 0.65 | NOS3 (0.52) | LCKSIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111269221-B | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2023-09-26 | — | — | CN | disclosed |