Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.64 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | ABCB11 | O95342 | 4/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | TSHR | P16473 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | SCN1A | P35498 | 3/20 | 0.64 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.64 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.64 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.64 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9401663 | 0.95 | KDM4E (0.58) | KDM4EHSD17B10KMT2ACYP2C9CYP1A2 | |
| SCHEMBL11829270 | 0.92 | CYP2C9 (0.67) | KDM4EHSD17B10KMT2ACYP2C9CYP1A2 | |
| SCHEMBL11004457 | 0.87 | CYP1A2 (0.68) | KDM4EHSD17B10KMT2ACYP2C9CYP1A2 | |
| SCHEMBL11004464 | 0.87 | CYP1A2 (0.68) | KDM4EHSD17B10KMT2ACYP2C9CYP1A2 | |
| SCHEMBL2996737 | 0.86 | MAPT (0.70) | KDM4EHSD17B10KMT2ACYP2C9CYP1A2 | |
| SCHEMBL7814723 | 0.85 | MAPT (0.53) | KDM4EHSD17B10KMT2ACYP2C9CYP1A2 | |
| SCHEMBL2995982 | 0.85 | NR3C2 (0.60) | KDM4EHSD17B10KMT2ACYP2C9CYP1A2 | |
| SCHEMBL9434276 | 0.84 | KDM4E (0.59) | KDM4EHSD17B10KMT2ACYP2C9CYP1A2 | |
| SCHEMBL9830581 | 0.84 | CACNA1B (0.63) | KMT2AADORA3CACNA1CCACNA1BMEN1 | |
| SCHEMBL9830577 | 0.84 | CACNA1B (0.63) | KMT2AADORA3CACNA1CCACNA1BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100261765-A1 | MINERALOCORTICOID RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. | 2010-10-14 | — | — | US | claimed |
| US-20100261765-A1 | MINERALOCORTICOID RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. | 2010-10-14 | — | — | US | disclosed |
| US-20100261765-A1 | MINERALOCORTICOID RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. | 2010-10-14 | — | — | US | disclosed |
| US-20100261765-A1 | MINERALOCORTICOID RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261765-A1 | MINERALOCORTICOID RECEPTOR MODULATORS | NR3C2, MC2R, NR3C1 | KDM4E 3139/4885HSD17B10 408/4885KMT2A 3249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.