Sugi Predict

Sugi Predict / Compounds / SCHEMBL3059494

SCHEMBL3059494

SCHEMBL3059494

COc1ccc(Nc2nc3nonc3nc2Nc2ccc(OC)cc2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 4/20 0.53
▸ MAPT P10636 4/20 0.53
▸ RAB9A P51151 3/20 0.53
▸ RECQL P46063 2/20 0.53
▸ L3MBTL1 Q9Y468 2/20 0.53
▸ KDM4E B2RXH2 1/20 0.53
▸ NPC1 O15118 1/20 0.53
▸ THRB P10828 1/20 0.53
▸ MAPK1 P28482 1/20 0.53
▸ NPSR1 Q6W5P4 1/20 0.53
▸ TDP1 Q9NUW8 1/20 0.53
▸ NR4A1 P22736 1/20 0.50
▸ HTT P42858 2/20 0.49
▸ ALDH1A1 P00352 1/20 0.49
▸ AURKA O14965 1/20 0.48
▸ SYK P43405 1/20 0.48
▸ MEN1 O00255 2/20 0.47
▸ KMT2A Q03164 2/20 0.47
▸ SMN1; SMN2 Q16637 1/20 0.47
▸ EGFR P00533 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21497146 0.91 GAA (0.48) GAAMAPTRAB9ARECQLL3MBTL1
SCHEMBL3054891 0.87 MAPT (0.49) GAAMAPTRAB9ARECQLL3MBTL1
SCHEMBL20569977 0.85 TUBB4A (0.49) GAAMAPTRAB9AKDM4ENPC1
SCHEMBL3053997 0.85 EGFR (0.51) MAPTSMN1; SMN2EGFRTP53
SCHEMBL22542819 0.83 SYK (0.54) GAAMAPTRAB9ARECQLL3MBTL1
SCHEMBL20570001 0.81 MAPT (0.54) GAAMAPTRAB9AKDM4ENPC1
SCHEMBL31741915 0.81 MAPT (0.54) GAAMAPTRAB9AKDM4ENPC1
SCHEMBL6509347 0.80 MAPT (0.56) GAAMAPTRAB9ARECQLL3MBTL1
SCHEMBL6509341 0.80 MAPT (0.56) GAAMAPTRAB9ARECQLL3MBTL1
SCHEMBL3063324 0.80 GAA (0.76) GAAMAPTRAB9ARECQLNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120178754-A1 Furazano '3, 4-B! Pyrazines and Their Use as Anti-Tumor Agents COMPASS PHARMACEUTICALS LLC (US) 2012-07-12 — — US claimed
US-20100222356-A1 Furazano '3, 4-B! Pyrazines and Their Use as Anti-Tumor Agents COMPASS PHARMACEUTICALS LLC (US) 2010-09-02 — — US claimed
US-20090131445-A1 Furazano '3, 4-B! Pyrazines and Their Use as Anti-Tumor Agents COMPASS PHARMACEUTICALS LLC (US) 2009-05-21 — — US claimed
EP-1799689-A1 FURAZANO `3, 4-B ! PYRAZYNES AND THEIR USE AS ANTI-TUMOR AGENTS Compass Pharmaceuticals LLC (US) 2007-06-27 — — EP claimed
WO-2006044402-A1 FURAZANO `3, 4-B ! PYRAZYNES AND THEIR USE AS ANTI-TUMOR AGENTS COMPASS PHARMACEUTICALS LLC (US) 2006-04-27 — — WO claimed
EP-3630115-B1 COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS UNIV VIRGINIA PATENT FOUNDATION (US) 2025-12-10 — — EP disclosed
US-11896591-B2 Compositions and methods for preparing and using mitochondrial uncouplers UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2024-02-13 — — US disclosed
WO-2023159248-A1 RE-SENSITIZING MULTIDRUG-RESISTANT (MDR) GRAM-NEGATIVE BACTERIA TO COLISTIN USING IONOPHORES THE REGENTS OF THE UNIVERSITY OF COLORADO A BODY CORPORATE (US) 2023-08-24 — — WO disclosed
US-20200323846-A1 COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS UNIVERSITY OF VIRGINA PATENT FOUNDATION (US) 2020-10-15 — — US disclosed
US-20200323846-A1 COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS UNIVERSITY OF VIRGINA PATENT FOUNDATION (US) 2020-10-15 — — US disclosed
EP-3630115-A1 COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS University Of Virginia Patent Foundation (US) 2020-04-08 — — EP disclosed
WO-2018217757-A1 COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2018-11-29 — — WO disclosed
US-20120178754-A1 Furazano '3, 4-B! Pyrazines and Their Use as Anti-Tumor Agents COMPASS PHARMACEUTICALS LLC (US) 2012-07-12 — — US disclosed
US-20100222356-A1 Furazano '3, 4-B! Pyrazines and Their Use as Anti-Tumor Agents COMPASS PHARMACEUTICALS LLC (US) 2010-09-02 — — US disclosed
US-20090131445-A1 Furazano '3, 4-B! Pyrazines and Their Use as Anti-Tumor Agents COMPASS PHARMACEUTICALS LLC (US) 2009-05-21 — — US disclosed
EP-1799689-A1 FURAZANO `3, 4-B ! PYRAZYNES AND THEIR USE AS ANTI-TUMOR AGENTS Compass Pharmaceuticals LLC (US) 2007-06-27 — — EP disclosed
WO-2006044402-A1 FURAZANO `3, 4-B ! PYRAZYNES AND THEIR USE AS ANTI-TUMOR AGENTS COMPASS PHARMACEUTICALS LLC (US) 2006-04-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100222356-A1 Furazano '3, 4-B! Pyrazines and Their Use as Anti-Tumor Agents CDC73, VHL, RB1 GAA 3448/4885MAPT 3908/4885RAB9A 2481/4885
US-20090131445-A1 Furazano '3, 4-B! Pyrazines and Their Use as Anti-Tumor Agents CDC73, RB1, CA5A GAA 3240/4885MAPT 4220/4885RAB9A 2171/4885
US-20120178754-A1 Furazano '3, 4-B! Pyrazines and Their Use as Anti-Tumor Agents CDC73, VHL, RB1 GAA 3448/4885MAPT 3908/4885RAB9A 2481/4885
US-11896591-B2 Compositions and methods for preparing and using mitochondrial uncouplers ACAD9, GPR119, NDUFAF1 GAA 811/4885MAPT 3834/4885RAB9A 411/4885
US-20200323846-A1 COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS ACAD9, GPR119, NDUFAF1 GAA 811/4885MAPT 3834/4885RAB9A 411/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.