Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 12/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | CDC42 | P60953 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26071728 | 1.00 | ROCK2 (0.44) | ROCK2PARP1CHEK1MAP2K1ALDH1A1 | |
| SCHEMBL28392020 | 0.85 | PARP1 (0.43) | ROCK2PARP1CHEK1 | |
| SCHEMBL5983565 | 0.82 | JAK2 (0.41) | ROCK2PARP1CHEK1ALDH1A1GRM5 | |
| SCHEMBL28397791 | 0.81 | PARP1 (0.66) | PARP1CHEK1MAP2K1ALDH1A1GRM5 | |
| SCHEMBL14771286 | 0.77 | CHEK1 (0.49) | ROCK2PARP1CHEK1 | |
| SCHEMBL30596160 | 0.77 | PIM1 (0.38) | PARP1CHEK1ALDH1A1GRM4 | |
| SCHEMBL26072355 | 0.77 | PIM1 (0.38) | PARP1CHEK1ALDH1A1GRM4 | |
| SCHEMBL15124778 | 0.76 | LMNA (0.44) | ALDH1A1ROCK1GRM4 | |
| SCHEMBL30576347 | 0.76 | LMNA (0.44) | ALDH1A1ROCK1GRM4 | |
| SCHEMBL6795337 | 0.74 | ROCK2 (0.59) | ROCK2PARP1CHEK1MAP2K1CDC42 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192479-A1 | TRICYCLIC IRAK INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |