Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | PARG | Q86W56 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 2/20 | 0.32 |
| ▸ | DPYD | Q12882 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | DAO | P14920 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26072355 | 1.00 | PIM1 (0.38) | PIM1HASPINALDH1A1HIPK2GRM4 | |
| SCHEMBL30596156 | 0.77 | ROCK2 (0.44) | ALDH1A1GRM4PARP1CHEK1 | |
| SCHEMBL26071728 | 0.77 | ROCK2 (0.44) | ALDH1A1GRM4PARP1CHEK1 | |
| SCHEMBL30576347 | 0.70 | LMNA (0.44) | ALDH1A1HIPK2GRM4PARGLMNA | |
| SCHEMBL15124778 | 0.70 | LMNA (0.44) | ALDH1A1HIPK2GRM4PARGLMNA | |
| SCHEMBL26134442 | 0.69 | IRAK4 (0.55) | — | |
| SCHEMBL26071731 | 0.69 | IRAK4 (0.55) | — | |
| SCHEMBL20641851 | 0.69 | DPYD (0.37) | PIM1HASPINALDH1A1PARP1DPYD | |
| SCHEMBL28803072 | 0.68 | ALDH1A1 (0.50) | ALDH1A1PARP1DPYDPKMCHEK1 | |
| SCHEMBL14605057 | 0.66 | DRD2 (0.42) | PIM1HASPINALDH1A1LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192479-A1 | TRICYCLIC IRAK INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |