Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 7/20 | 0.73 |
| ▸ | TSHR | P16473 | 4/20 | 0.73 |
| ▸ | BLM | P54132 | 1/20 | 0.73 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.51 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9424581 | 0.88 | PDE1C (0.64) | GAATSHRBLMPDE1CALDH1A1 | |
| SCHEMBL3028393 | 0.86 | GAA (0.66) | GAATSHRBLMHTTHSD17B10 | |
| SCHEMBL13088047 | 0.85 | PDE1C (0.61) | GAATSHRBLMMAPK10PDE1C | |
| SCHEMBL10830286 | 0.82 | PDE1C (0.70) | TSHRPDE1CALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL3004824 | 0.81 | PDE1C (0.69) | TSHRHTTPDE1CALDH1A1MEN1 | |
| SCHEMBL9424586 | 0.80 | CACNA1B (0.56) | GAATSHRBLMPDE1CCACNA1B | |
| SCHEMBL17701111 | 0.79 | ALDH1A1 (0.67) | GAATSHRBLMMAPK10HTT | |
| SCHEMBL7818687 | 0.78 | GAA (0.67) | GAATSHRBLMMAPK10HTT | |
| SCHEMBL11735173 | 0.77 | KMT2A (0.53) | GAATSHRBLMMAPK10HTT | |
| SCHEMBL7817808 | 0.77 | THRB (0.59) | GAATSHRBLMHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100261765-A1 | MINERALOCORTICOID RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. | 2010-10-14 | — | — | US | claimed |
| US-20100261765-A1 | MINERALOCORTICOID RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261765-A1 | MINERALOCORTICOID RECEPTOR MODULATORS | NR3C2, MC2R, NR3C1 | GAA 4804/4885TSHR 151/4885BLM 4298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.