Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | NAPRT | Q6XQN6 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | MC3R | P41968 | 1/20 | 0.42 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | F3 | P13726 | 1/20 | 0.40 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.40 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrazine SCHEMBL4712089 | 1.00 | ACHE (0.54) | ACHENAPRTTSHRADORA3MC4R | |
| Pyrazine SCHEMBL28327835 | 0.88 | ALDH1A1 (0.50) | ACHENAPRTTSHRADORA3MC4R | |
| Oxamate SCHEMBL10805693 | 0.86 | LDHA (0.60) | ACHENAPRTTSHRADORA3MC4R | |
| Oxamate SCHEMBL11103998 | 0.86 | LDHA (0.60) | ACHENAPRTTSHRADORA3MC4R | |
| Pyridine SCHEMBL9065525 | 0.86 | NAPRT (0.60) | ACHENAPRTTSHRF7F3 | |
| Pyridine SCHEMBL1164077 | 0.86 | NAPRT (0.60) | ACHENAPRTTSHRF7F3 | |
| Pyrazine SCHEMBL27860453 | 0.84 | NAPRT (0.47) | NAPRTTSHRADORA3MC4RADRA1A | |
| Pyridine SCHEMBL27840495 | 0.83 | NAPRT (0.56) | ACHENAPRTTSHRF7F3 | |
| Oxalic Acid SCHEMBL27623456 | 0.80 | NAPRT (0.45) | NAPRTTSHRADORA3MC4RADRA1A | |
| Pyridine SCHEMBL1070164 | 0.79 | NAPRT (0.60) | ACHENAPRTTSHRADORA3F7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3983072-A1 | PYRAZINE CARBAMATES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2022-04-20 | — | — | EP | disclosed |
| EP-3983072-A1 | PYRAZINE CARBAMATES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2022-04-20 | — | — | EP | disclosed |
| CN-113950357-A | Pyrazine carbamates and their use as GluN2B receptor modulators | 詹森药业有限公司 | 2022-01-18 | — | — | CN | disclosed |
| CN-113950357-A | Pyrazine carbamates and their use as GluN2B receptor modulators | 詹森药业有限公司 | 2022-01-18 | — | — | CN | disclosed |
| WO-2020249796-A1 | PYRAZINE CARBAMATES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-17 | — | — | WO | disclosed |
| US-20200392155-A1 | PYRAZINE CARBAMATES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-17 | — | — | US | disclosed |
| WO-2020249796-A1 | PYRAZINE CARBAMATES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-17 | — | — | WO | disclosed |
| US-20170267895-A9 | POLISHING SLURRY FOR CMP AND POLISHING METHOD | HITACHI CHEMICAL COMPANY, LTD. (JP) | 2017-09-21 | — | — | US | disclosed |
| US-20150315419-A1 | POLISHING SLURRY FOR CMP AND POLISHING METHOD | HITACHI CHEMICAL COMPANY, LTD. (JP) | 2015-11-05 | — | — | US | disclosed |
| US-20140065825-A1 | POLISHING SLURRY FOR CMP AND POLISHING METHOD | HITACHI CHEMICAL CO., LTD. (JP) | 2014-03-06 | — | — | US | disclosed |
| US-20090143357-A1 | HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHK1 | ICOS CORPORATION (US) | 2009-06-04 | — | — | US | disclosed |
| EP-1936673-A1 | POLISHING SOLUTION FOR CMP AND METHOD OF POLISHING | Hitachi Chemical Co., Ltd. (JP) | 2008-06-25 | — | — | EP | disclosed |
| EP-1869020-A1 | HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHKl | ICOS Corporation (US) | 2007-12-26 | — | — | EP | disclosed |
| US-20070117394-A1 | Polishing slurry for CMP and polishing method | HITACHI CHEMICAL CO., LTD. (JP) | 2007-05-24 | — | — | US | disclosed |
| WO-2006105262-A1 | HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHKl | ICOS CORPORATION (US) | 2006-10-05 | — | — | WO | disclosed |
| US-6706732-B1 | PROPHYLACTIC AND THERAPEUTIC EFFECT ON MYOCARDIAL INFARCTION AND ACCOMPANYING DYSFUNCTIONS, ARRHYTHMIA, UNSTABLE ANGINA, CARDIAC HYPERTROPHY, ETC.; SODIUM-PROTON EXCHANGE INHIBITION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2004-03-16 | — | — | US | disclosed |
| EP-0803502-B1 | Process for the preparation of optically active piperazine-2-carboxylic acid derivatives | LONZA AG (CH) | 2002-06-26 | — | — | EP | disclosed |
| EP-1182194-A1 | PERNASAL PREPARATIONS | Takeda Chemical Industries, Ltd. (JP) | 2002-02-27 | — | — | EP | disclosed |
| EP-0803502-A2 | Process for the preparation of optically active piperazine-2-carboxylic acid derivatives | LONZA AG (CH) | 1997-10-29 | — | — | EP | disclosed |
| EP-0537937-A2 | Substituted pyrazino 2,3-D pyrimidinones as angiotensin II antagonists | MERCK & CO. INC. (US) | 1993-04-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200392155-A1 | PYRAZINE CARBAMATES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | GRIN2B, GRIN2A, GRIN2C | ACHE 793/4885NAPRT 588/4885TSHR 445/4885 |
| US-20090143357-A1 | HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHK1 | CHEK1, CHEK2, PCNA | ACHE 2611/4885NAPRT 1952/4885TSHR 4180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.