Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14356107 | 1.00 | KIF11 (0.49) | KIF11NPC1RAB9AALDH1A1LMNA | |
| SCHEMBL28885052 | 0.89 | KIF11 (0.49) | KIF11NPC1RAB9AALDH1A1LMNA | |
| SCHEMBL6476023 | 0.89 | KIF11 (0.43) | KIF11NPC1RAB9AALDH1A1LMNA | |
| SCHEMBL12762284 | 0.87 | KCNN4 (0.48) | KIF11NPC1RAB9AALDH1A1LMNA | |
| SCHEMBL10276699 | 0.86 | KIF11 (0.46) | KIF11NPC1RAB9AALDH1A1LMNA | |
| SCHEMBL4199968 | 0.84 | KCNN4 (0.56) | KIF11ALDH1A1ALOX15MAPK1TDP1 | |
| SCHEMBL12225852 | 0.82 | KIF11 (0.49) | KIF11ALDH1A1LMNAMAPK1KCNN4 | |
| SCHEMBL4363002 | 0.82 | KIF11 (0.49) | KIF11ALDH1A1LMNAMAPK1KCNN4 | |
| SCHEMBL3249628 | 0.82 | KIF11 (0.43) | KIF11NPC1RAB9AALDH1A1LMNA | |
| SCHEMBL6304679 | 0.82 | NPC1 (0.47) | KIF11NPC1RAB9AALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250236633-A1 | SYNTHESIS OF ISOMERICALLY PURE POLYOL-BASED PHOSPHORAMIDITES | Roche Sequencing Solutions, Inc. (US) | 2025-07-24 | — | — | US | disclosed |
| EP-4499655-A1 | SYNTHESIS OF ISOMERICALLY PURE POLYOL-BASED PHOSPHORAMIDITES | F. Hoffmann-La Roche AG (CH) | 2025-02-05 | — | — | EP | disclosed |
| WO-2023186842-A1 | SYNTHESIS OF ISOMERICALLY PURE POLYOL-BASED PHOSPHORAMIDITES | F. HOFFMANN-LA ROCHE AG (CH) | 2023-10-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250236633-A1 | SYNTHESIS OF ISOMERICALLY PURE POLYOL-BASED PHOSPHORAMIDITES | PARG, PPA1, PGM2 | KIF11 2422/4885NPC1 4801/4885RAB9A 4234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.