Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR3 | P46089 | 1/20 | 0.46 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.44 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18000262 | 1.00 | GPR3 (0.46) | GPR3ALKBH5FTOKDM4ENQO2 | |
| SCHEMBL27769612 | 0.90 | KDM4E (0.40) | GPR3ALKBH5FTOKDM4ENQO2 | |
| SCHEMBL24136214 | 0.82 | ALDH1A1 (0.32) | GPR3ALKBH5FTOKDM4ENQO2 | |
| SCHEMBL13548554 | 0.79 | ALKBH5 (0.52) | GPR3ALKBH5FTOKDM4ENQO2 | |
| SCHEMBL21432468 | 0.78 | GPR3 (0.45) | GPR3ALKBH5FTOKDM4ENQO2 | |
| SCHEMBL30480838 | 0.78 | KDM4E (0.50) | GPR3ALKBH5FTOKDM4ENQO2 | |
| SCHEMBL26547562 | 0.78 | KDM4E (0.50) | GPR3ALKBH5FTOKDM4ENQO2 | |
| SCHEMBL19643772 | 0.77 | DHFR (0.43) | CASP1CASP7CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL1355293 | 0.76 | DHFR (0.45) | GPR3ALKBH5FTOKDM4ENQO2 | |
| SCHEMBL18000203 | 0.76 | GPR3 (0.41) | GPR3ALKBH5FTOKDM4ENQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2023-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | GPR3 3611/4885ALKBH5 3013/4885FTO 4687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.