Sugi Predict

Sugi Predict / Compounds / SCHEMBL30623744

SCHEMBL30623744

SCHEMBL30623744

O=C(NCc1cc2c3ccccc3nc(S)n2n1)c1ccccc1OC(F)(F)F

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.40
▸ HTT P42858 2/20 0.40
▸ F2R P25116 1/20 0.39
▸ EGFR P00533 1/20 0.38
▸ BTK Q06187 1/20 0.38
▸ PTGER4 P35408 1/20 0.38
▸ HCN1 O60741 1/20 0.38
▸ KCNK3 O14649 3/20 0.37
▸ KCNK9 Q9NPC2 3/20 0.37
▸ ADRA2A P08913 2/20 0.37
▸ NPY5R Q15761 2/20 0.37
▸ MCHR1 Q99705 2/20 0.37
▸ KDM4E B2RXH2 3/20 0.37
▸ HPGD P15428 2/20 0.37
▸ TP53 P04637 2/20 0.37
▸ GLA P06280 1/20 0.37
▸ LMNA P02545 2/20 0.37
▸ RAB9A P51151 2/20 0.37
▸ MAPK1 P28482 1/20 0.37
▸ NOD2 Q9HC29 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26629778 1.00 ALDH1A1 (0.40) ALDH1A1HTTF2REGFRBTK
SCHEMBL31461693 0.89 ALDH1A1 (0.44) ALDH1A1HTTF2REGFRBTK
SCHEMBL31461717 0.89 EGFR (0.42) ALDH1A1HTTF2REGFRBTK
SCHEMBL31461667 0.89 ALDH1A1 (0.42) ALDH1A1HTTF2REGFRBTK
SCHEMBL31571954 0.88 HPGD (0.52) ALDH1A1HTTKDM4EHPGDTP53
SCHEMBL31461721 0.87 F2R (0.41) ALDH1A1HTTF2REGFRBTK
SCHEMBL31461697 0.86 ALDH1A1 (0.41) ALDH1A1HTTF2REGFRBTK
SCHEMBL31461702 0.86 ALDH1A1 (0.41) ALDH1A1HTTF2REGFRBTK
SCHEMBL31461714 0.86 ADRA2A (0.42) ALDH1A1HTTF2REGFRBTK
SCHEMBL26629775 0.86 ALDH1A1 (0.41) ALDH1A1HTTF2REGFRBTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260028355-A1 PROTEOLYSIS TARGETING CHIMERA (PROTAC) COMPOSITIONS USING UBIQUITIN CONJUGATING ENZYME LIGANDS BERG, KARA ANN 2026-01-29 — — US disclosed
US-20250262309-A1 PROTEOLYSIS TARGETING CHIMERA (PROTAC) COMPOSITIONS USING UBIQUITIN CONJUGATING ENZYME LIGANDS BERG, KARA ANN 2025-08-21 — — US disclosed
WO-2025090847-A1 ESTROGEN RECEPTOR DEGRADERS AND THEIR USE IN THE TREATMENT OF CANCER BPGBIO, INC. (US) 2025-05-01 — — WO disclosed
CN-119546341-A Proteolytic targeting chimeric (PROTAC) compositions using ubiquitin conjugated enzyme ligands 布普格生物制药公司 2025-02-28 — — CN disclosed
EP-4429705-A1 PROTEOLYSIS TARGETING CHIMERA (PROTAC) COMPOSITIONS USING UBIQUITIN CONJUGATING ENZYME LIGANDS Berg LLC (US) 2024-09-18 — — EP disclosed
WO-2023205219-A1 PROTEOLYSIS TARGETING CHIMERA (PROTAC) COMPOSITIONS USING UBIQUITIN CONJUGATING ENZYME LIGANDS BERG LLC (US) 2023-10-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250262309-A1 PROTEOLYSIS TARGETING CHIMERA (PROTAC) COMPOSITIONS USING UBIQUITIN CONJUGATING ENZYME LIGANDS UBE3C, UBE3A, MDM2 ALDH1A1 3014/4885HTT 876/4885F2R 1657/4885
US-20260028355-A1 PROTEOLYSIS TARGETING CHIMERA (PROTAC) COMPOSITIONS USING UBIQUITIN CONJUGATING ENZYME LIGANDS UBE2T, UBE3C, UBE2E1 ALDH1A1 3389/4885HTT 1824/4885F2R 800/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.