Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 7/20 | 0.55 |
| ▸ | CYP1B1 | Q16678 | 7/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.55 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CTSA | P10619 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30632881 | 0.84 | CBFB (0.39) | CYP1A1CYP1B1CYP1A2MAPK1CTSA | |
| SCHEMBL30632897 | 0.81 | NFE2L2 (0.50) | CYP1A1CYP1B1NFE2L2TRPA1 | |
| SCHEMBL30633073 | 0.78 | NPC1 (0.36) | CYP1A2KDM4EMAPK1NFE2L2NPC1 | |
| SCHEMBL30632943 | 0.78 | NFE2L2 (0.33) | CYP1A2MAPK1NFE2L2NPC1RAB9A | |
| SCHEMBL6471044 | 0.76 | CYP1A2 (0.56) | CYP1A1CYP1B1CYP1A2KDM4ENFE2L2 | |
| SCHEMBL6471039 | 0.76 | CYP1A2 (0.56) | CYP1A1CYP1B1CYP1A2KDM4ENFE2L2 | |
| SCHEMBL28473621 | 0.76 | CYP1A1 (0.37) | CYP1A1CYP1B1KDM4ENFE2L2EGFR | |
| SCHEMBL30632941 | 0.76 | HTR2A (0.38) | — | |
| SCHEMBL30632963 | 0.74 | NFE2L2 (0.55) | KDM4ENFE2L2RELANPC1RAB9A | |
| SCHEMBL30632879 | 0.73 | ALDH1A1 (0.39) | CYP1A2AMY1ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12286426-B2 | Heterocyclic mitochondrial activity inhibitors and uses thereof | Université de Montréal (CA) | 2025-04-29 | — | — | US | disclosed |
| CN-111886234-B | Heterocyclic mitochondrial activity inhibitors and uses thereof | 蒙特利尔大学 | 2023-12-15 | — | — | CN | disclosed |
| US-20230357221-A1 | HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF | UNIV MONTREAL (CA) | 2023-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230357221-A1 | HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF | IDH2, TFAM, IDH1 | CYP1A1 1340/4885CYP1B1 1021/4885CYP1A2 1179/4885 |
| US-12286426-B2 | Heterocyclic mitochondrial activity inhibitors and uses thereof | IDH2, TFAM, IDH1 | CYP1A1 1340/4885CYP1B1 1021/4885CYP1A2 1179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.