SCHEMBL30632521

SCHEMBL30632521

COC(=O)C(c1cc(N2CCC3(CC2)CC(Oc2ccc4nnc(-c5ccccc5O)cc4c2)C3)no1)C(C)C

nearest known ligand 0.34

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 1/20 0.34
▸ NPY5R Q15761 2/20 0.32
▸ TACR3 P29371 1/20 0.31
▸ VHL P40337 2/20 0.31
▸ SMARCA2 P51531 1/20 0.31
▸ SMARCA4 P51532 1/20 0.31
▸ PBRM1 Q86U86 2/20 0.31
▸ ACACB O00763 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26684930 1.00 MAPT (0.34) MAPTNPY5RTACR3VHLSMARCA2
SCHEMBL30632478 0.93 PBRM1 (0.33) MAPTNPY5RVHLSMARCA2SMARCA4
SCHEMBL26685136 0.93 PBRM1 (0.33) MAPTNPY5RVHLSMARCA2SMARCA4
SCHEMBL30632490 0.89 TACR3 (0.32) MAPTNPY5RTACR3
SCHEMBL26685067 0.89 TACR3 (0.32) MAPTNPY5RTACR3
SCHEMBL30632497 0.80 — —
SCHEMBL26684810 0.80 — —
SCHEMBL26888967 0.78 MAPT (0.37) MAPTTACR3SMARCA2SMARCA4PBRM1
SCHEMBL31294046 0.78 MAPT (0.35) MAPTTACR3SMARCA2SMARCA4PBRM1
SCHEMBL30632492 0.76 MAPT (0.34) MAPTTACR3SMARCA2SMARCA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119998278-A Compounds and uses thereof 福宏治疗公司 2025-05-13 — — CN disclosed
EP-4522278-A1 BENZOYPARAZINE PYRAZINES ANE THEIR USES Foghorn Therapeutics Inc. (US) 2025-03-19 — — EP disclosed
WO-2023220129-A1 BENZOYPARAZINE PYRAZINES ANE THEIR USES FOGHORN THERAPEUTICS INC. (US) 2023-11-16 — — WO disclosed
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