Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 11/20 | 0.48 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.46 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3053314 | 0.86 | SLC22A12 (0.52) | SLC22A12HTR6PTGDR2PTPN2PTPN1 | |
| SCHEMBL3062553 | 0.84 | HTR6 (0.51) | SLC22A12HTR6PTGDR2PTPN2PTPN1 | |
| SCHEMBL13139525 | 0.82 | SLC22A12 (0.47) | SLC22A12HTR6PTGDR2HIF1ABRD4 | |
| SCHEMBL3063588 | 0.82 | HTR6 (0.51) | SLC22A12HTR6PTGDR2HIF1ABRD4 | |
| SCHEMBL3049389 | 0.81 | MEN1 (0.50) | SLC22A12HTR6PTGDR2NTSR1 | |
| SCHEMBL13178662 | 0.80 | SLC22A12 (0.45) | SLC22A12HTR6PTGDR2HIF1ABRD4 | |
| SCHEMBL3061861 | 0.78 | MEN1 (0.48) | HTR6NTSR1 | |
| SCHEMBL3057526 | 0.75 | ALDH1A1 (0.43) | HTR6NTSR1 | |
| SCHEMBL3059970 | 0.69 | HTR6 (0.68) | HTR6NTSR1 | |
| SCHEMBL3769130 | 0.68 | SLC22A12 (0.70) | SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492559-B2 | Substituted indole compounds | GRUENENTHAL GMBH (DE) | 2013-07-23 | — | — | US | disclosed |
| US-20100222324-A1 | Substituted Indole Compounds | GRUENENTHAL GMBH (DE) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222324-A1 | Substituted Indole Compounds | BDKRB1, BDKRB2, EDNRB | SLC22A12 3817/4885HTR6 103/4885PTGDR2 90/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.