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SCHEMBL3064159

SCHEMBL3064159

CCN(c1cccc(CN(C(=O)OC(C)(C)C)c2ccc(F)cc2)c1)C1CC1

nearest known ligand 0.42

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ CHRM1 P11229 10/20 0.42
▸ CHRM3 P20309 10/20 0.42
▸ CHRM2 P08172 8/20 0.42
▸ HDAC8 Q9BY41 2/20 0.39
▸ HDAC6 Q9UBN7 2/20 0.39
▸ HDAC1 Q13547 1/20 0.39
▸ CHRM5 P08912 2/20 0.39
▸ ACHE P22303 2/20 0.38
▸ MEN1 O00255 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ KCNQ4 P56696 2/20 0.37
▸ KCNQ5 Q9NR82 2/20 0.37
▸ DRD2 P14416 1/20 0.36
▸ DRD3 P35462 1/20 0.36
▸ NR1H4 Q96RI1 1/20 0.36
▸ KDM1A O60341 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3049232 0.88 CHRM1 (0.43) CHRM1CHRM3CHRM2HDAC8HDAC6
SCHEMBL3059109 0.88 ACHE (0.39) CHRM1CHRM3CHRM2HDAC6CHRM5
Hydrochloric Acid SCHEMBL3064216 0.87 ACHE (0.39) CHRM1CHRM3CHRM2HDAC6CHRM5
SCHEMBL3823468 0.85 AAK1 (0.38) CHRM1CHRM3CHRM2CHRM5ACHE
SCHEMBL3821794 0.84 OPRM1 (0.39) CHRM1CHRM3CHRM2CHRM5ACHE
SCHEMBL3819363 0.82 ATM (0.39) CHRM1CHRM3CHRM2CHRM5ACHE
SCHEMBL4734946 0.81 LMNA (0.58) MEN1KMT2A
SCHEMBL3058213 0.80 CHRM1 (0.44) CHRM1CHRM3CHRM2HDAC1CHRM5
SCHEMBL3065671 0.79 KCNQ4 (0.41) CHRM1CHRM3CHRM2HDAC8HDAC6
SCHEMBL4738981 0.79 LMNA (0.41) CHRM1CHRM3CHRM2HDAC8HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100267697-A1 ION CHANNEL MODULATORS WYETH (US) 2010-10-21 — — US disclosed
US-20100267697-A1 ION CHANNEL MODULATORS WYETH (US) 2010-10-21 — — US disclosed
EP-2099754-A1 ION CHANNEL MODULATORS Wyeth a Corporation of the State of Delaware (US) 2009-09-16 — — EP disclosed
EP-2097379-A1 CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS Wyeth a Corporation of the State of Delaware (US) 2009-09-09 — — EP disclosed
EP-2091917-A1 ION CHANNEL MODULATORS Wyeth a Corporation of the State of Delaware (US) 2009-08-26 — — EP disclosed
WO-2008073936-A1 CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS WYETH (US) 2008-06-19 — — WO disclosed
WO-2008073936-A1 CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS WYETH (US) 2008-06-19 — — WO disclosed
WO-2008073929-A1 ION CHANNEL MODULATORS WYETH (US) 2008-06-19 — — WO disclosed
WO-2008073461-A2 ION CHANNEL MODULATORS WYETH (US) 2008-06-19 — — WO disclosed
WO-2008073934-A1 ION CHANNEL MODULATORS WYETH (US) 2008-06-19 — — WO disclosed
WO-2008073934-A1 ION CHANNEL MODULATORS WYETH (US) 2008-06-19 — — WO disclosed
WO-2008073929-A1 ION CHANNEL MODULATORS WYETH (US) 2008-06-19 — — WO disclosed
WO-2008073461-A2 ION CHANNEL MODULATORS WYETH (US) 2008-06-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100267697-A1 ION CHANNEL MODULATORS CACNA1E, CACNA1A, CACNA1S CHRM1 215/4885CHRM3 217/4885CHRM2 223/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.