Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5823744 | 1.00 | POLB (0.59) | POLBTDP1L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL31370787 | 0.81 | DUT (0.38) | POLBTDP1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL1518274 | 0.80 | POLB (0.71) | POLBTDP1L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL18616173 | 0.80 | MCL1 (0.40) | L3MBTL1MAPT | |
| SCHEMBL13490857 | 0.78 | POLB (0.66) | POLBTDP1L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1779408 | 0.78 | MAPT (0.58) | POLBTDP1L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2263898 | 0.77 | DUT (0.52) | POLBTDP1L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2819961 | 0.77 | ALDH1A1 (0.50) | POLBTDP1ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL14522478 | 0.76 | ICMT (0.58) | — | |
| SCHEMBL16146216 | 0.75 | MCL1 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137542-B | Pyridone dicarboxamides as bromodomain inhibitors | 葛兰素史克知识产权第二有限公司 | 2023-10-27 | — | — | CN | disclosed |