Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | NCF1 | P14598 | 7/20 | 0.61 |
| ▸ | BACE1 | P56817 | 2/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | NQO2 | P16083 | 1/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.50 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11349234 | 0.81 | NCF1 (0.56) | LMNAHPGDSMN1; SMN2NCF1BACE1 | |
| SCHEMBL7805413 | 0.81 | NCF1 (0.76) | NCF1BACE1ALDH1A1TLR8 | |
| SCHEMBL23452956 | 0.80 | NCF1 (0.90) | NCF1BACE1 | |
| SCHEMBL266444 | 0.79 | LMNA (0.64) | LMNAHPGDSMN1; SMN2NCF1ALOX15 | |
| SCHEMBL28010962 | 0.79 | LMNA (0.64) | LMNAHPGDSMN1; SMN2ALOX15KDM4E | |
| SCHEMBL30065410 | 0.79 | HPGD (0.64) | LMNAHPGDSMN1; SMN2ALOX15KDM4E | |
| SCHEMBL29877118 | 0.79 | LMNA (0.64) | LMNAHPGDSMN1; SMN2NCF1ALOX15 | |
| SCHEMBL396614 | 0.79 | HPGD (0.64) | LMNAHPGDSMN1; SMN2ALOX15KDM4E | |
| SCHEMBL11350348 | 0.79 | ALDH1A1 (0.59) | LMNAHPGDSMN1; SMN2NCF1KDM4E | |
| SCHEMBL23412800 | 0.79 | NCF1 (0.82) | NCF1BACE1TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1359915-A4 | UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM (US) | 2004-07-21 | — | — | EP | claimed |
| EP-1359915-A1 | UROTENSIN-II RECEPTOR ANTAGONISTS | Smithkline Beecham (US) | 2003-11-12 | — | — | EP | claimed |
| WO-2003013523-A1 | SH3 PROTEIN DOMAINS AND THEIR LIGANDS | ADELAIDE RESEARCH & INNOVATION PTY LTD (AU) | 2003-02-20 | — | — | WO | claimed |
| WO-2002058702-A1 | UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (GB) | 2002-08-01 | — | — | WO | claimed |
| US-9932320-B2 | Quinoline-based kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-04-03 | — | — | US | disclosed |
| US-9464076-B2 | Benzothiophene derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2016-10-11 | — | — | US | disclosed |
| US-9464076-B2 | Benzothiophene derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2016-10-11 | — | — | US | disclosed |
| US-9464076-B2 | Benzothiophene derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2016-10-11 | — | — | US | disclosed |
| US-20160024060-A1 | BENZOTHIOPHENE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2016-01-28 | — | — | US | disclosed |
| US-20160024060-A1 | BENZOTHIOPHENE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2016-01-28 | — | — | US | disclosed |
| US-20160024060-A1 | BENZOTHIOPHENE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2016-01-28 | — | — | US | disclosed |
| EP-2975037-A1 | BENZOTHIOPHENE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2016-01-20 | — | — | EP | disclosed |
| US-4279912-A | ANTIALLERGENS, BRONCHODILATORS | ROUSSEL UCLAF (FR) | 1981-07-21 | — | — | US | disclosed |
| US-4247699-A | REACTION OF AN ISATOIC ANHYDRIDE WITH MALONONITRILE FOLLOWED BY TREATMENT WITH A STRONG ACID OR BASE | PFIZER INC. (US) | 1981-01-27 | — | — | US | disclosed |
| US-4175193-A | INTERMEDIATES FOR 1-OXO-1H-6-ALKOXYPYRIMDO(1,2-A)QUINOLINE-2-CARBOXYLIC ACID AND ESTER ANTIALLERGENS | PFIZER INC. (US) | 1979-11-20 | — | — | US | disclosed |
| US-4075343-A | Anti-allergenic 5-alkoxyimidazo[1,2-A]quinoline-2-carboxylic acids and derivatives thereof | PFIZER INC. (US) | 1978-02-21 | — | — | US | disclosed |
| US-4066766-A | 1-Oxo-6-substituted pyrimido [1,2-a]quinoline-2-carboxylic acids and derivatives thereof and their use as antiallergy agents | PFIZER INC. (US) | 1978-01-03 | — | — | US | disclosed |
| US-4031217-A | PYRIMIDINE-QUINOLINE COMPOUNDS | PFIZER INC. (US) | 1977-06-21 | — | — | US | disclosed |
| US-4017625-A | Anti-allergic N-(5-tetrazolyl)-1-oxo-1H-6-alkoxypyrimido-[1,2-a]quinoline-2-carboxamides and intermediates therefor | PFIZER INC. (US) | 1977-04-12 | — | — | US | disclosed |
| US-4014881-A | ANTIULCER AGENTS | PFIZER INC. (US) | 1977-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160024060-A1 | BENZOTHIOPHENE DERIVATIVE | PDE10A, PDE5A, PDE3B | LMNA 3843/4885HPGD 1863/4885SMN1; SMN2 2785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.