Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1B | P01584 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 3/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26654138 | 1.00 | IL1B (0.40) | IL1BP2RX7PSEN1PSEN2APH1B | |
| SCHEMBL25217659 | 0.89 | HCAR1 (0.48) | GPR119HCAR1KDM4EMAPTTHRB | |
| SCHEMBL26654108 | 0.81 | SMARCA2 (0.52) | IL1BP2RX7SRCEGFRABL1 | |
| SCHEMBL30658054 | 0.81 | SMARCA2 (0.52) | IL1BP2RX7SRCEGFRABL1 | |
| SCHEMBL34469726 | 0.81 | OXTR (0.36) | GPR119KMT2AHCAR1POLBMEN1 | |
| SCHEMBL23291564 | 0.78 | HSP90AA1 (0.44) | KMT2ALMNAPOLBSRCEGFR | |
| SCHEMBL30658060 | 0.78 | IL1B (0.40) | IL1BP2RX7PSEN1PSEN2APH1B | |
| SCHEMBL26653943 | 0.78 | IL1B (0.40) | IL1BP2RX7PSEN1PSEN2APH1B | |
| SCHEMBL30658015 | 0.76 | IL1B (0.39) | IL1BP2RX7PSEN1PSEN2APH1B | |
| SCHEMBL26653970 | 0.76 | IL1B (0.39) | IL1BP2RX7PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4522279-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | Foghorn Therapeutics Inc. (US) | 2025-03-19 | — | — | EP | disclosed |
| WO-2023220134-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2023-11-16 | — | — | WO | disclosed |