Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methylene Blue Cation. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 4/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 4/20 | 1.00 |
| ▸ | RECQL | P46063 | 4/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
| ▸ | TST | Q16762 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | APP | P05067 | 11/20 | 0.97 |
| ▸ | MAPT | P10636 | 7/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.97 |
| ▸ | POLB | P06746 | 3/20 | 0.97 |
| ▸ | BLM | P54132 | 3/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.97 |
| ▸ | ATM | Q13315 | 3/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylene Blue Cation SCHEMBL29357640 | 1.00 | THRB (1.00) | THRBMAPK1RECQLTDP1SMN1; SMN2 | |
| Methylene Blue Cation SCHEMBL29668541 | 1.00 | THRB (1.00) | THRBMAPK1RECQLTDP1SMN1; SMN2 | |
| Methylene Blue Cation SCHEMBL29389009 | 1.00 | THRB (1.00) | THRBMAPK1RECQLTDP1SMN1; SMN2 | |
| Methylene Blue Cation SCHEMBL4227551 | 0.99 | APP (1.00) | THRBMAPK1RECQLTDP1SMN1; SMN2 | |
| Methylene Blue Cation SCHEMBL30021960 | 0.97 | APP (0.97) | THRBMAPK1RECQLTDP1SMN1; SMN2 | |
| Methylene Blue Cation SCHEMBL29441543 | 0.97 | APP (1.00) | THRBMAPK1RECQLTDP1SMN1; SMN2 | |
| Methylene Blue Cation SCHEMBL127316 | 0.97 | APP (1.00) | THRBMAPK1RECQLTDP1SMN1; SMN2 | |
| SCHEMBL13116706 | 0.87 | APP (0.81) | THRBMAPK1RECQLTDP1SMN1; SMN2 | |
| SCHEMBL14271006 | 0.87 | APP (0.81) | THRBMAPK1RECQLTDP1SMN1; SMN2 | |
| SCHEMBL18070252 | 0.85 | APP (0.77) | THRBMAPK1RECQLTDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4303580-A1 | KIT FOR MAKING ELECTRON DONOR VISIBLE AND METHOD FOR MAKING ELECTRON DONOR VISIBLE | Shachihata Inc. (JP) | 2024-01-10 | — | — | EP | disclosed |
| US-20230384230-A1 | KIT FOR MAKING ELECTRON DONOR VISIBLE AND METHOD FOR MAKING ELECTRON DONOR VISIBLE | SHACHIHATA INC. (JP) | 2023-11-30 | — | — | US | disclosed |
| CN-116997794-A | Electron donor visualization kit and electron donor visualization method | 沙奇哈塔株式会社 | 2023-11-03 | — | — | CN | disclosed |