Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methylene Blue Cation. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 4/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 4/20 | 1.00 |
| ▸ | RECQL | P46063 | 4/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
| ▸ | TST | Q16762 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | APP | P05067 | 11/20 | 0.97 |
| ▸ | MAPT | P10636 | 7/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.97 |
| ▸ | POLB | P06746 | 3/20 | 0.97 |
| ▸ | BLM | P54132 | 3/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.97 |
| ▸ | ATM | Q13315 | 3/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylene Blue Cation SCHEMBL29357640 | 1.00 | THRB (1.00) | THRBMAPK1RECQLTDP1SMN1; SMN2 | |
| Methylene Blue Cation SCHEMBL29389009 | 1.00 | THRB (1.00) | THRBMAPK1RECQLTDP1SMN1; SMN2 | |
| Methylene Blue Cation SCHEMBL30664737 | 1.00 | THRB (1.00) | THRBMAPK1RECQLTDP1SMN1; SMN2 | |
| Methylene Blue Cation SCHEMBL4227551 | 0.99 | APP (1.00) | THRBMAPK1RECQLTDP1SMN1; SMN2 | |
| Methylene Blue Cation SCHEMBL30021960 | 0.97 | APP (0.97) | THRBMAPK1RECQLTDP1SMN1; SMN2 | |
| Methylene Blue Cation SCHEMBL29441543 | 0.97 | APP (1.00) | THRBMAPK1RECQLTDP1SMN1; SMN2 | |
| Methylene Blue Cation SCHEMBL127316 | 0.97 | APP (1.00) | THRBMAPK1RECQLTDP1SMN1; SMN2 | |
| SCHEMBL13116706 | 0.87 | APP (0.81) | THRBMAPK1RECQLTDP1SMN1; SMN2 | |
| SCHEMBL14271006 | 0.87 | APP (0.81) | THRBMAPK1RECQLTDP1SMN1; SMN2 | |
| SCHEMBL18070252 | 0.85 | APP (0.77) | THRBMAPK1RECQLTDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12173355-B2 | Nano-plasmonic molecular probes and methods of use | DUKE UNIVERSITY (US) | 2024-12-24 | — | — | US | claimed |
| US-20240401113-A1 | AMPLIFICATION SYSTEMS FOR NANO-PLASMONIC MOLECULAR PROBES AND METHODS THEREOF | DUKE UNIVERSITY | 2024-12-05 | — | — | US | claimed |
| US-20240402164-A1 | PLASMONIC CAGED NANOPLATFORMS AND METHODS THEREOF | DUKE UNIVERSITY | 2024-12-05 | — | — | US | claimed |
| US-20240156993-A1 | PLASMONICS SENSING NANOPLATFORMS FOR HUMAN STEM CELL APPLICATIONS AND METHODS THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2024-05-16 | — | — | US | claimed |
| CN-117462704-A | Solid oral compositions containing dyes for use in endoscopic diagnostics | 科斯莫科技有限公司 | 2024-01-30 | — | — | CN | claimed |
| CN-115768906-A | Plasma sensing nano platform for human stem cell application and method thereof | 杜克大学 | 2023-03-07 | — | — | CN | claimed |
| EP-4097249-A2 | PLASMONICS SENSING NANOPLATFORMS FOR HUMAN STEM CELL APPLICATIONS AND METHODS THEREOF | Duke University (US) | 2022-12-07 | — | — | EP | claimed |
| US-20260139295-A1 | NANO-PLASMONIC MOLECULAR PROBES AND METHODS OF USE | DUKE UNIVERSITY (US) | 2026-05-21 | — | — | US | disclosed |
| US-20260097043-A1 | NOVEL FORMULATIONS AND VEHICLES | WISTA LABORATORIES LTD. (SG) | 2026-04-09 | — | — | US | disclosed |
| US-12590058-B2 | Photooxidation of 2,4,6-trimethylphenol | DSM IP ASSETS B.V. (NL) | 2026-03-31 | — | — | US | disclosed |
| US-20260048066-A1 | TREATMENT OF NEURODEGENERATIVE DISORDERS UTILISING METHYLTHIONINIUM (MT)-CONTAINING COMPOUNDS | WISTA LABORATORIES LTD (SG) | 2026-02-19 | — | — | US | disclosed |
| US-20260014548-A1 | Method for Manufacturing Porous Ionic Polymers for Water Remediation | THE UNIVERSITY OF SOUTHERN MISSISSIPPI (US) | 2026-01-15 | — | — | US | disclosed |
| WO-2025265086-A1 | ENGINEERED STEM CELL DERIVED GRAFTS AND METHODS OF USE THEREOF | MINUTIA, INC. (US) | 2025-12-26 | — | — | WO | disclosed |
| EP-4097249-A2 | PLASMONICS SENSING NANOPLATFORMS FOR HUMAN STEM CELL APPLICATIONS AND METHODS THEREOF | Duke University (US) | 2022-12-07 | — | — | EP | disclosed |
| EP-4086605-A1 | SOLUTION AND METHOD FOR HISTOPROCESSING OF BIOLOGICAL SAMPLES | Roche Diagnostics Hematology, Inc. (US) | 2022-11-09 | — | — | EP | disclosed |
| EP-4059968-A1 | POLYMERIZABLE COMPOSITION, VEHICLE, AND CURED OBJECT AND PRODUCTION METHOD THEREFOR | ADEKA CORPORATION (JP) | 2022-09-21 | — | — | EP | disclosed |
| US-20220258147-A1 | PHOTOCATALYSIS USING MIE RESONANCES OF Cu2O DIELECTRIC NANOSTRUCTURES | The Board of Regents for the Oklahoma Agricultural and Mechanical Colleges | 2022-08-18 | — | — | US | disclosed |
| US-20220241203-A1 | METHOD FOR PRODUCTION OF LIPOSOMES | UNIVERSIDADE DO MINHO (PT) | 2022-08-04 | — | — | US | disclosed |
| CN-109422739-B | Deuterated indoleamine 2, 3-dioxygenase inhibitor and application thereof | 药捷安康(南京)科技股份有限公司 | 2022-07-12 | — | — | CN | disclosed |
| EP-2721391-B1 | SOLUTION AND METHOD FOR HISTOPROCESSING OF BIOLOGICAL SAMPLES | ROCHE DIAGNOSTICS HEMATOLOGY INC (US) | 2022-04-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260048066-A1 | TREATMENT OF NEURODEGENERATIVE DISORDERS UTILISING METHYLTHIONINIUM (MT)-CONTAINING COMPOUNDS | MAPT, PARK7, TARDBP | THRB 3170/4885MAPK1 3344/4885RECQL 2064/4885 |
| US-20260139295-A1 | NANO-PLASMONIC MOLECULAR PROBES AND METHODS OF USE | METTL16, SLTM, BRCA1 | THRB 318/4885MAPK1 4039/4885RECQL 1662/4885 |
| US-12590058-B2 | Photooxidation of 2,4,6-trimethylphenol | HMOX2, ADH1A, HMOX1 | THRB 220/4885MAPK1 1863/4885RECQL 3542/4885 |
| US-20260014548-A1 | Method for Manufacturing Porous Ionic Polymers for Water Remediation | SLC6A9, PARG, SLC6A12 | THRB 1505/4885MAPK1 1635/4885RECQL 3140/4885 |
| US-20260097043-A1 | NOVEL FORMULATIONS AND VEHICLES | TPMT, PARK7, HTT | THRB 1978/4885MAPK1 4503/4885RECQL 1506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.