Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | ROS1 | P08922 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | STK3 | Q13188 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30672471 | 0.80 | MERTK (0.47) | MAP4K2MAP4K4PIM1PRKACAFLT3 | |
| SCHEMBL30672116 | 0.78 | BRD4 (0.41) | MAP4K2MKNK2PLK4ROCK2RPS6KA5 | |
| SCHEMBL29626186 | 0.78 | POLB (0.44) | MAP4K2MKNK2PLK4ROCK2RPS6KA5 | |
| SCHEMBL30672148 | 0.78 | MERTK (0.42) | MAP4K2MKNK2PLK4ROCK2RPS6KA5 | |
| SCHEMBL30672466 | 0.76 | ALDH1A1 (0.43) | MAP4K2MKNK2PLK4ROCK2RPS6KA5 | |
| SCHEMBL30672493 | 0.75 | ALDH1A1 (0.43) | MAP4K2MKNK2PLK4ROCK2RPS6KA5 | |
| SCHEMBL30672459 | 0.75 | SMN1; SMN2 (0.38) | MAP4K2MKNK2PLK4ROCK2RPS6KA5 | |
| SCHEMBL30672509 | 0.72 | PLAUR (0.36) | MAP4K2MKNK2PLK4ROCK2RPS6KA5 | |
| SCHEMBL29626109 | 0.71 | TYRO3 (0.45) | NTRK1ALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL30185699 | 0.71 | HPGD (0.49) | MAP4K2MKNK2PLK4ROCK2RPS6KA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3436461-B1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORP (US) | 2023-11-01 | — | — | EP | disclosed |