Fialuridine

Fialuridine

SCHEMBL30674

O=c1[nH]c(=O)n([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2F)cc1I

nearest known ligand 0.77

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PYGM P11217 3/20 0.77
TK1 P04183 2/20 0.58
TK2 O00142 2/20 0.55
P2RY6 Q15077 5/20 0.52
P2RY14 Q15391 3/20 0.52
CDA P32320 1/20 0.47
SLC28A1 O00337 1/20 0.47
SLC28A2 O43868 1/20 0.47
SLC29A1 Q99808 1/20 0.47
SLC28A3 Q9HAS3 1/20 0.47
LMNA P02545 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fialuridine SCHEMBL1533997 1.00 PYGM (0.77) PYGMTK1TK2P2RY6P2RY14
Fialuridine SCHEMBL3084377 1.00 PYGM (0.77) PYGMTK1TK2P2RY6P2RY14
Fialuridine SCHEMBL13702050 1.00 PYGM (0.77) PYGMTK1TK2P2RY6P2RY14
Fialuridine SCHEMBL3084382 1.00 PYGM (0.77) PYGMTK1TK2P2RY6P2RY14
Fialuridine SCHEMBL9059414 1.00 PYGM (0.77) PYGMTK1TK2P2RY6P2RY14
Fialuridine SCHEMBL24359134 1.00 PYGM (0.77) PYGMTK1TK2P2RY6P2RY14
Fialuridine SCHEMBL768344 1.00 PYGM (0.77) PYGMTK1TK2P2RY6P2RY14
Fialuridine SCHEMBL773510 1.00 PYGM (0.77) PYGMTK1TK2P2RY6P2RY14
Fialuridine SCHEMBL20769829 1.00 PYGM (0.77) PYGMTK1TK2P2RY6P2RY14
Fialuridine SCHEMBL12658448 1.00 PYGM (0.77) PYGMTK1TK2P2RY6P2RY14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1132 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116514888-A Fluorescent probe and preparation method and application thereof 深圳大学 2023-08-01 CN claimed
US-11021497-B2 Compositions and methods for synthesis of phosphorylated molecules THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-06-01 US claimed
US-20200239500-A1 Compositions and Methods for Synthesis of Phosphorylated Molecules THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2020-07-30 US claimed
WO-2019195494-A1 COMPOSITIONS AND METHODS FOR SYNTHESIS OF PHOSPHORYLATED MOLECULES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2019-10-10 WO claimed
EP-3423473-A2 VIRUS VECTORS EXPRESSING MULTIPLE EPITOPES OF TUMOR ASSOCIATED ANTIGENS FOR INDUCING ANTITUMOR IMMUNITY New York University (US) 2019-01-09 EP claimed
WO-2018161092-A1 INDUCTION AND ENHANCEMENT OF ANTITUMOR IMMUNITY INVOLVING VIRUS VECTORS EXPRESSING MULTIPLE EPITOPES OF TUMOR ASSOCIATED ANTIGENS AND IMMUNE CHECKPOINT INHIBITORS OR PROTEINS NEW YORK UNIVERSITY (US) 2018-09-07 WO claimed
US-20180000912-A1 Virus Vectors Expressing Multiple Epitopes of Tumor Associated Antigens For Inducing Antitumor Immunity NEW YORK UNIVERSITY 2018-01-04 US claimed
US-20070264241-A1 Compounds for Enhanced Cancer Therapy ZGENE A/S (DK) 2007-11-15 US claimed
US-20070259832-A1 Nucleotide mimics and their prodrugs BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2007-11-08 US claimed
US-20040072168-A1 Novel deoxynucleoside kinase enzyme variants KNECHT WOLFGANG (SE) 2004-04-15 US claimed
US-20040059104-A1 Nucleotide mimics and their prodrugs BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2004-03-25 US claimed
US-20030228285-A1 Bipartite T-cell factor (Tcf)-responsive promoter BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2003-12-11 US claimed
EP-1283874-A2 NOVEL DEOXYNUCLEOSIDE KINASE ENZYME VARIANTS Knecht, Wolfgang (DK) 2003-02-19 EP claimed
WO-2001088106-A2 NOVEL DEOXYRIBONUCLESIDE KINASE ENZYME MULTI-SUBSTRATE VARIANTS KNECHT WOLFGANG (DK) 2001-11-22 WO claimed
EP-0010205-B1 5-SUBSTITUTED 1-(2'-DEOXY-2'-SUBSTITUTED-BETA-D-ARABINOFURANOSYL) PYRIMIDINE NUCLEOSIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Sloan-Kettering Institute For Cancer Research (US) 1983-05-04 EP claimed
US-4211773-A VIRICIDES, ANTITUMOR AGENTS SLOAN KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1980-07-08 US claimed
EP-0010205-A1 5-Substituted 1-(2'-deoxy-2'-substituted-beta-D-arabinofuranosyl) pyrimidine nucleosides and pharmaceutical compositions containing them Sloan-Kettering Institute For Cancer Research (US) 1980-04-30 EP claimed
WO-2026106956-A1 DISULFIDE-STABILIZED NOROVIRUS VIRUS-LIKE PARTICLE DESIGN MERCK SHARP & DOHME LLC (US) 2026-05-21 WO disclosed
US-4211773-A VIRICIDES, ANTITUMOR AGENTS SLOAN KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1980-07-08 US disclosed
EP-0010205-A1 5-Substituted 1-(2'-deoxy-2'-substituted-beta-D-arabinofuranosyl) pyrimidine nucleosides and pharmaceutical compositions containing them Sloan-Kettering Institute For Cancer Research (US) 1980-04-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070259832-A1 Nucleotide mimics and their prodrugs NUDT14, ENTPD5, MTAP PYGM 590/4885TK1 62/4885TK2 207/4885
US-20200239500-A1 Compositions and Methods for Synthesis of Phosphorylated Molecules PIK3CA, CHAMP1, TYMP PYGM 173/4885TK1 22/4885TK2 68/4885
US-20070264241-A1 Compounds for Enhanced Cancer Therapy TYMP, BAD, NUDT1 PYGM 694/4885TK1 16/4885TK2 8/4885
US-11021497-B2 Compositions and methods for synthesis of phosphorylated molecules PIK3CA, CHAMP1, TYMP PYGM 173/4885TK1 22/4885TK2 68/4885
US-20040059104-A1 Nucleotide mimics and their prodrugs NUDT14, ENTPD5, MTAP PYGM 590/4885TK1 62/4885TK2 207/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.