Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAT | P00750 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26961690 | 0.72 | GAA (0.36) | PLATBTK | |
| SCHEMBL29796810 | 0.72 | GAA (0.36) | PLATBTK | |
| SCHEMBL29270822 | 0.72 | PLAT (0.30) | PLATBTK | |
| SCHEMBL31374883 | 0.69 | HDAC1 (0.43) | HDAC6HDAC1HDAC8TP53LMNA | |
| SCHEMBL30830306 | 0.67 | — | — | |
| SCHEMBL30675699 | 0.67 | HDAC1 (0.46) | HDAC6HDAC1HDAC8TP53LMNA | |
| SCHEMBL30675667 | 0.67 | HDAC1 (0.49) | HDAC6HDAC1HDAC8TP53LMNA | |
| SCHEMBL26962195 | 0.65 | GAA (0.35) | HDAC6 | |
| SCHEMBL29796985 | 0.64 | RXRA (0.37) | HDAC6HDAC1HDAC8TP53LMNA | |
| SCHEMBL8853758 | 0.63 | LMNA (0.54) | HDAC6HDAC1HDAC8TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116964048-A | Bicyclic tetrahydroazepine derivatives for the treatment of cancer | 豪夫迈·罗氏有限公司 | 2023-10-27 | — | — | CN | disclosed |