Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.56 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.56 |
| ▸ | KMO | O15229 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1665694 | 1.00 | SMN1; SMN2 (0.59) | SMN1; SMN2KMT2AMAPTLMNAMEN1 | |
| SCHEMBL16869528 | 0.86 | KMO (0.55) | SMN1; SMN2KMT2AMAPTLMNAMEN1 | |
| SCHEMBL4093686 | 0.86 | SMN1; SMN2 (0.61) | SMN1; SMN2KMT2AMAPTLMNAMEN1 | |
| SCHEMBL2744730 | 0.86 | SMN1; SMN2 (0.59) | SMN1; SMN2KMT2AMAPTLMNAMEN1 | |
| SCHEMBL1398597 | 0.85 | KDM4E (0.66) | KMT2AMAPTMEN1GAAL3MBTL1 | |
| SCHEMBL29784244 | 0.85 | KDM4E (0.66) | KMT2AMAPTMEN1GAAL3MBTL1 | |
| SCHEMBL8806160 | 0.83 | GAA (0.69) | SMN1; SMN2KMT2AMAPTLMNAMEN1 | |
| SCHEMBL11062391 | 0.83 | SMN1; SMN2 (0.55) | SMN1; SMN2KMT2AMAPTLMNAMEN1 | |
| SCHEMBL10708221 | 0.83 | NPC1 (0.56) | SMN1; SMN2KMT2AMAPTLMNAMEN1 | |
| SCHEMBL31078204 | 0.83 | KMO (0.55) | SMN1; SMN2KMT2AMAPTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023250157-A9 | INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS LIPOAMIDE DEHYDROGENASE | CORNELL UNIVERSITY (US) | 2024-01-25 | — | — | WO | disclosed |
| WO-2023250157-A1 | INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS LIPOAMIDE DEHYDROGENASE | CORNELL UNIVERSITY (US) | 2023-12-28 | — | — | WO | disclosed |