Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMO | Q99835 | 2/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32672541 | 0.82 | SLC6A9 (0.44) | SMOHCRTR1HCRTR2CYP2C9HDAC1 | |
| SCHEMBL19852721 | 0.81 | SMO (0.49) | NPC1RAB9ASMOHCRTR1HCRTR2 | |
| SCHEMBL19852652 | 0.79 | SMO (0.45) | NPC1RAB9ASMOHCRTR1HCRTR2 | |
| SCHEMBL32672556 | 0.79 | SMO (0.44) | NPC1RAB9ASMOCYP2C9HDAC1 | |
| SCHEMBL30511079 | 0.79 | GAA (0.53) | NPC1RAB9ASMOCYP2C9HDAC1 | |
| SCHEMBL17636193 | 0.79 | GAA (0.53) | NPC1RAB9ASMOCYP2C9HDAC1 | |
| SCHEMBL19852677 | 0.78 | NPC1 (0.45) | NPC1RAB9ASMOHCRTR1HCRTR2 | |
| SCHEMBL12643221 | 0.77 | MAPT (0.49) | NPC1SMOTP53MAPTALDH1A1 | |
| SCHEMBL29436267 | 0.77 | MAPT (0.49) | NPC1SMOTP53MAPTALDH1A1 | |
| SCHEMBL32672593 | 0.76 | SMO (0.47) | NPC1SMOCYP2C9HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260042770-A1 | NOVEL SULFONES AND THEIR USE AS NEUROPROTECTIVE AND/OR NEURORESTORATIVE AGENTS | GENECODE (EE) | 2026-02-12 | — | — | US | disclosed |
| EP-4561996-A1 | [4-[5-(METHYLSULFONYL)-PHENYL]PIPERAZIN-1-YL]-(PHENYL)METHANONE DERIVATIVES AND SIMILAR COMPOUNDS WITH GFR ALPHA 1-RET ACTIVITY AS NEUROPROTECTIVE AGENTS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | Genecode (EE) | 2025-06-04 | — | — | EP | disclosed |
| CN-119894875-A | [4- [5- (Methylsulfonyl) -phenyl ] piperazin-1-yl ] - (phenyl) methanone derivatives and similar compounds having gfrα1-RET activity as neuroprotective agents for the treatment of neurological disorders | 基因密码公司 | 2025-04-25 | — | — | CN | disclosed |
| WO-2024023287-A1 | [4-[5-(METHYLSULFONYL)-PHENYL]PIPERAZIN-1-YL]-(PHENYL)METHANONE DERIVATIVES AND SIMILAR COMPOUNDS WITH GFR ALPHA 1-RET ACTIVITY AS NEUROPROTECTIVE AGENTS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | GENECODE (EE) | 2024-02-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260042770-A1 | NOVEL SULFONES AND THEIR USE AS NEUROPROTECTIVE AND/OR NEURORESTORATIVE AGENTS | BDNF, CNR1, GFRA1 | NPC1 155/4885RAB9A 1154/4885SMO 2590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.