Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.48 |
| ▸ | AMY1A | P0DUB6 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29359707 | 0.98 | TRPV4 (0.50) | TRPV4AMY1AMAPTNPC1HSP90AA1 | |
| SCHEMBL585492 | 0.98 | TRPV4 (0.50) | TRPV4AMY1AMAPTNPC1HSP90AA1 | |
| SCHEMBL30259322 | 0.83 | TRPV4 (0.38) | TRPV4AMY1AMAPTNPC1HSP90AA1 | |
| SCHEMBL29958505 | 0.80 | ALDH1A1 (0.52) | TRPV4AMY1AMAPTNPC1HTR2A | |
| SCHEMBL929274 | 0.80 | ALDH1A1 (0.52) | TRPV4AMY1AMAPTNPC1HTR2A | |
| SCHEMBL16282203 | 0.79 | CRHR1 (0.44) | TRPV4AMY1AMAPTNPC1HSP90AA1 | |
| SCHEMBL18000003 | 0.79 | CRHR1 (0.44) | TRPV4AMY1AMAPTNPC1HSP90AA1 | |
| SCHEMBL20526464 | 0.78 | ALDH1A1 (0.50) | TRPV4AMY1AMAPTNPC1HTR2A | |
| SCHEMBL2127233 | 0.77 | TRPV4 (0.55) | TRPV4MAPTALDH1A1LMNAMEN1 | |
| SCHEMBL29636402 | 0.77 | TRPV4 (0.55) | TRPV4MAPTALDH1A1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117510495-A | Pyridazine compounds for inhibiting NLRP3 | 万特斯治疗美国公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-117500792-A | Pyridazine compounds for inhibiting NLRP3 | 万特斯治疗美国公司 | 2024-02-02 | — | — | CN | disclosed |