Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 5/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30699675 | 0.76 | KDM1A (0.40) | KDM1AMAOAMAOBALOX5THRA | |
| SCHEMBL30699627 | 0.75 | APP (0.31) | — | |
| SCHEMBL30989561 | 0.74 | SMN1; SMN2 (0.38) | KDM1AMAOBALOX5SMN1; SMN2THRA | |
| SCHEMBL25359554 | 0.70 | KDM1A (0.49) | KDM1AMAOAMAOBALOX5APFEN1 | |
| SCHEMBL30699586 | 0.69 | — | — | |
| SCHEMBL30259750 | 0.69 | KDM1A (0.56) | KDM1AMAOAMAOBALOX5APFEN1 | |
| SCHEMBL11217127 | 0.68 | ALOX5AP (0.45) | KDM1AMAOAMAOBALOX5APFEN1 | |
| SCHEMBL9823890 | 0.68 | KDM1A (0.50) | KDM1AMAOAMAOBTHRATHRB | |
| SCHEMBL3410935 | 0.68 | KDM1A (0.45) | KDM1AMAOAMAOBALOX5APFEN1 | |
| SCHEMBL25165363 | 0.67 | PIN1 (0.40) | MAOBALOX5APFEN1PIN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023244713-A1 | QUINAZOLINE DERIVATIVES, COMPOSITIONS AND METHODS THEREOF | ENSEM THERAPEUTICS, INC. (US) | 2023-12-21 | — | — | WO | disclosed |