Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.35 |
| ▸ | LIPE | Q05469 | 7/20 | 0.34 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30700450 | 0.83 | GPR119 (0.38) | KDM4EABL1LMNASCN9AHSD11B1 | |
| SCHEMBL30699891 | 0.80 | GAA (0.43) | KDM4EABL1LMNAGAATDP1 | |
| SCHEMBL30700102 | 0.80 | GAA (0.43) | KDM4EABL1LMNAGAATDP1 | |
| SCHEMBL30700321 | 0.80 | MALT1 (0.36) | KDM4EABL1LMNAGAATDP1 | |
| SCHEMBL30700149 | 0.79 | LOXL2 (0.36) | KDM4EABL1LMNAGAATDP1 | |
| SCHEMBL30700517 | 0.79 | KDM4E (0.47) | KDM4EABL1LMNAGAATDP1 | |
| SCHEMBL30700376 | 0.78 | ABHD6 (0.39) | KDM4EABL1LMNAGAATDP1 | |
| SCHEMBL30700104 | 0.78 | KDM4E (0.42) | KDM4EABL1LMNAGAATDP1 | |
| SCHEMBL26739545 | 0.77 | MGLL (0.39) | SCN9ALIPEABHD6HCRTR1CYP2D6 | |
| SCHEMBL26631156 | 0.77 | MGLL (0.39) | SCN9ALIPEABHD6HCRTR1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543870-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2025-04-30 | — | — | EP | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | disclosed |