Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 3/20 | 0.35 |
| ▸ | ATXN2 | Q99700 | 3/20 | 0.35 |
| ▸ | MGLL | Q99685 | 6/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.32 |
| ▸ | GPR6 | P46095 | 1/20 | 0.32 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30700195 | 1.00 | ENPP2 (0.35) | ENPP2ATXN2MGLLCHRNA7RORC | |
| SCHEMBL30700414 | 1.00 | ENPP2 (0.35) | ENPP2ATXN2MGLLCHRNA7RORC | |
| SCHEMBL31308016 | 0.82 | ENPP2 (0.41) | ENPP2ATXN2MGLL | |
| SCHEMBL31307999 | 0.82 | ENPP2 (0.41) | ENPP2ATXN2MGLL | |
| SCHEMBL30700573 | 0.82 | ENPP2 (0.41) | ENPP2ATXN2MGLL | |
| SCHEMBL30699868 | 0.82 | MGLL (0.34) | MGLLRORCBTKCYP11B1CYP11B2 | |
| SCHEMBL30699966 | 0.81 | LOXL2 (0.33) | ENPP2 | |
| SCHEMBL30700509 | 0.81 | CHRM4 (0.34) | MGLL | |
| SCHEMBL30700336 | 0.81 | ENPP2 (0.36) | ENPP2ATXN2MGLLFFAR4GPR6 | |
| SCHEMBL30700444 | 0.81 | MGLL (0.41) | ENPP2ATXN2MGLLCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543870-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2025-04-30 | — | — | EP | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | disclosed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | disclosed |