Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 3/20 | 0.36 |
| ▸ | ATXN2 | Q99700 | 3/20 | 0.36 |
| ▸ | GPR6 | P46095 | 2/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 2/20 | 0.33 |
| ▸ | LIPE | Q05469 | 1/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30699891 | 0.83 | GAA (0.43) | ENPP2ATXN2GPR6FFAR4LMNA | |
| SCHEMBL30700102 | 0.83 | GAA (0.43) | ENPP2ATXN2GPR6FFAR4LMNA | |
| SCHEMBL30700261 | 0.81 | ENPP2 (0.35) | ENPP2ATXN2GPR6FFAR4MGLL | |
| SCHEMBL30700414 | 0.81 | ENPP2 (0.35) | ENPP2ATXN2GPR6FFAR4MGLL | |
| SCHEMBL30700195 | 0.81 | ENPP2 (0.35) | ENPP2ATXN2GPR6FFAR4MGLL | |
| SCHEMBL30700595 | 0.77 | GPR119 (0.37) | GPR119LIPE | |
| SCHEMBL30700077 | 0.76 | MGLL (0.38) | ENPP2ATXN2ALDH1A1PKMUSP2 | |
| SCHEMBL30700507 | 0.76 | MGLL (0.44) | ENPP2ATXN2MGLL | |
| SCHEMBL30700153 | 0.76 | MGLL (0.44) | ENPP2ATXN2MGLL | |
| SCHEMBL30700727 | 0.75 | GPR119 (0.50) | ENPP2ATXN2GPR6FFAR4GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543870-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2025-04-30 | — | — | EP | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | disclosed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | disclosed |