Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 2/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.39 |
| ▸ | TEAD1 | P28347 | 3/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | F2R | P25116 | 3/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30700764 | 1.00 | MGLL (0.46) | MGLLMCHR1TEAD1PDE2APIM1 | |
| SCHEMBL30700699 | 0.88 | P2RX7 (0.38) | MGLLF2R | |
| SCHEMBL30700290 | 0.85 | MGLL (0.62) | MGLLPDE2APIM1BTK | |
| SCHEMBL30700009 | 0.85 | MGLL (0.46) | MGLLPDE2APIM1PIK3CAPRKAA2 | |
| SCHEMBL30700322 | 0.85 | MGLL (0.44) | MGLLMCHR1TEAD1PDE2AF2R | |
| SCHEMBL30700147 | 0.85 | MGLL (0.46) | MGLLPDE2APIM1PIK3CAPRKAA2 | |
| SCHEMBL27289691 | 0.85 | MGLL (0.46) | MGLLPDE2APIM1PIK3CAPRKAA2 | |
| SCHEMBL30700176 | 0.85 | MGLL (0.46) | MGLLPDE2APIM1PIK3CAPRKAA2 | |
| SCHEMBL30700174 | 0.85 | MGLL (0.46) | MGLLPDE2APIM1PIK3CAPRKAA2 | |
| SCHEMBL27289695 | 0.85 | MGLL (0.46) | MGLLPDE2APIM1PIK3CAPRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543870-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2025-04-30 | — | — | EP | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | disclosed |