Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 6/20 | 0.43 |
| ▸ | RBP4 | P02753 | 6/20 | 0.36 |
| ▸ | GPR183 | P32249 | 2/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.33 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30700022 | 0.93 | MGLL (0.43) | MGLLGPR183ADAMTS4ADAMTS5P2RX7 | |
| SCHEMBL30700887 | 0.90 | MGLL (0.40) | MGLL | |
| SCHEMBL30700423 | 0.87 | MGLL (0.44) | MGLL | |
| SCHEMBL30700869 | 0.86 | MGLL (0.37) | MGLL | |
| SCHEMBL30700294 | 0.83 | MGLL (0.40) | MGLL | |
| SCHEMBL30700859 | 0.83 | MGLL (0.40) | MGLL | |
| SCHEMBL30700591 | 0.82 | MGLL (0.40) | MGLL | |
| SCHEMBL30700357 | 0.82 | MGLL (0.41) | MGLL | |
| SCHEMBL30700516 | 0.81 | MGLL (0.44) | MGLL | |
| SCHEMBL30700348 | 0.81 | MGLL (0.44) | MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | disclosed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | disclosed |