Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 9/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.37 |
| ▸ | ATXN2 | Q99700 | 3/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.34 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30700218 | 0.93 | MGLL (0.43) | MGLLPIM1ENPP2ATXN2PIK3CA | |
| SCHEMBL30700887 | 0.90 | MGLL (0.40) | MGLLPAK1 | |
| SCHEMBL30700591 | 0.88 | MGLL (0.40) | MGLLPIM1PAK1BTK | |
| SCHEMBL30700714 | 0.87 | MGLL (0.43) | MGLL | |
| SCHEMBL30700358 | 0.87 | MGLL (0.41) | MGLLPIM1PAK1 | |
| SCHEMBL30700357 | 0.87 | MGLL (0.41) | MGLLPIM1BTK | |
| SCHEMBL30700373 | 0.86 | MGLL (0.43) | MGLLPIM1PAK1 | |
| SCHEMBL30700859 | 0.85 | MGLL (0.40) | MGLLPIM1ENPP2ATXN2PAK1 | |
| SCHEMBL30700516 | 0.84 | MGLL (0.44) | MGLLPIM1PAK1 | |
| SCHEMBL30700290 | 0.83 | MGLL (0.62) | MGLLPIM1PDE2ABTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543870-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2025-04-30 | — | — | EP | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | disclosed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | disclosed |