Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KLK7 | P49862 | 2/20 | 0.41 |
| ▸ | CASR | P41180 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | UBE2M | P61081 | 3/20 | 0.38 |
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3070275 | 1.00 | EPHX2 (0.44) | EPHX2EPHX1ATMALDH1A1KLK7 | |
| SCHEMBL3070270 | 1.00 | EPHX2 (0.44) | EPHX2EPHX1ATMALDH1A1KLK7 | |
| SCHEMBL3064874 | 0.77 | CASR (0.48) | EPHX2EPHX1ATMALDH1A1KLK7 | |
| SCHEMBL3072576 | 0.76 | KLK7 (0.47) | EPHX2EPHX1ATMALDH1A1KLK7 | |
| SCHEMBL3052471 | 0.73 | CASR (0.53) | EPHX2EPHX1ATMALDH1A1KLK7 | |
| SCHEMBL4017006 | 0.72 | HDAC6 (0.52) | EPHX2EPHX1ATMKLK7CASR | |
| SCHEMBL13091919 | 0.70 | CASR (0.48) | EPHX2EPHX1ATMKLK7CASR | |
| SCHEMBL28421952 | 0.69 | EPHX2 (0.68) | EPHX2EPHX1ALDH1A1KLK7MEN1 | |
| SCHEMBL28424785 | 0.68 | MEN1 (0.67) | EPHX2EPHX1ALDH1A1KLK7MEN1 | |
| SCHEMBL4817710 | 0.68 | ATM (0.55) | EPHX2EPHX1ATMALDH1A1NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100261796-A1 | Use of Novel Compounds for IBD Treatment | FERRING B.V. (NL) | 2010-10-14 | — | — | US | claimed |
| US-20100105777-A1 | AMIDE OR THIOAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PAIN | CARA THERAPEUTICS, INC. (US) | 2010-04-29 | — | — | US | claimed |
| US-7504538-B2 | Amide or thioamide derivatives and their use in the treatment of pain | CARA THERAPEUTICS, INC. (US) | 2009-03-17 | — | — | US | claimed |
| US-20070197653-A1 | Amide or thioamide derivatives and their use in the treatment of pain | CARA THERAPEUTICS, INC. (US) | 2007-08-23 | — | — | US | claimed |
| US-20100261796-A1 | Use of Novel Compounds for IBD Treatment | FERRING B.V. (NL) | 2010-10-14 | — | — | US | disclosed |
| US-20100105777-A1 | AMIDE OR THIOAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PAIN | CARA THERAPEUTICS, INC. (US) | 2010-04-29 | — | — | US | disclosed |
| US-7504538-B2 | Amide or thioamide derivatives and their use in the treatment of pain | CARA THERAPEUTICS, INC. (US) | 2009-03-17 | — | — | US | disclosed |
| US-20070197653-A1 | Amide or thioamide derivatives and their use in the treatment of pain | CARA THERAPEUTICS, INC. (US) | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261796-A1 | Use of Novel Compounds for IBD Treatment | TPMT, FABP2, SLC10A2 | EPHX2 1218/4885EPHX1 1043/4885ATM 4358/4885 |
| US-20070197653-A1 | Amide or thioamide derivatives and their use in the treatment of pain | TRPA1, TRPV1, TST | EPHX2 1131/4885EPHX1 868/4885ATM 3579/4885 |
| US-20100105777-A1 | AMIDE OR THIOAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PAIN | TRPA1, TRPV1, TST | EPHX2 1131/4885EPHX1 868/4885ATM 3579/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.