Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | PRKAG1 | P54619 | 5/20 | 0.32 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.32 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.32 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.32 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.32 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.32 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30540792 | 0.77 | RAB9A (0.42) | PIM1PIM2RAB9ANPC1KDM4E | |
| SCHEMBL5562287 | 0.73 | KDM4E (0.41) | PIM1PIM2RAB9ANPC1KDM4E | |
| SCHEMBL31586483 | 0.70 | GAA (0.38) | PIM1PIM2RAB9ANPC1GSK3B | |
| SCHEMBL3402451 | 0.70 | GAA (0.44) | PIM1PIM2PRKAG1PRKAA1PRKAB1 | |
| SCHEMBL14721720 | 0.68 | PRKAG1 (0.33) | PRKAG1PRKAA1PRKAB1PRKAA2PRKAB2 | |
| SCHEMBL30823749 | 0.68 | GSK3B (0.42) | PIM1PIM2MAPTKDM4EGSK3B | |
| SCHEMBL15740705 | 0.68 | PIM1 (0.33) | PIM1PIM2RAB9ANPC1ALDH1A1 | |
| SCHEMBL31190772 | 0.68 | PIM1 (0.33) | PIM1PIM2RAB9ANPC1ALDH1A1 | |
| SCHEMBL26905298 | 0.67 | KDM4E (0.50) | PIM1PIM2RAB9ANPC1MAPT | |
| SCHEMBL28926587 | 0.66 | SMN1; SMN2 (0.45) | RAB9ANPC1MAPTKDM4CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4540255-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2025-04-23 | — | — | EP | disclosed |
| WO-2023244615-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-12-21 | — | — | WO | disclosed |