Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.44 |
| ▸ | HTT | P42858 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | NR1D1 | P20393 | 7/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29068719 | 0.82 | ALDH1A1 (0.43) | HTTL3MBTL1GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL14571796 | 0.78 | MAPT (0.46) | MAPTHTTKDM4EL3MBTL1GAA | |
| SCHEMBL12780984 | 0.76 | ALDH1A1 (0.42) | GAAKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8652324 | 0.76 | SMN1; SMN2 (0.41) | L3MBTL1GAAALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5182378 | 0.75 | KMT2A (0.51) | MAPTHTTKDM4EL3MBTL1GAA | |
| SCHEMBL3057494 | 0.74 | CA2 (0.41) | GAAALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL4060893 | 0.74 | ALDH1A1 (0.54) | MAPTHTTKDM4EL3MBTL1GAA | |
| SCHEMBL27748238 | 0.74 | L3MBTL1 (0.44) | KDM4EL3MBTL1GAAPOLBKMT2A | |
| SCHEMBL7521198 | 0.74 | MAPT (0.46) | MAPTHTTKDM4EL3MBTL1GAA | |
| SCHEMBL29068721 | 0.73 | CA2 (0.37) | GAAALDH1A1TDP1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100267774-A1 | P38 MAP KINASE INHIBITORS | CHROMA THERAPEUTICS LTD. (GB) | 2010-10-21 | — | — | US | disclosed |
| US-20100267774-A1 | P38 MAP KINASE INHIBITORS | CHROMA THERAPEUTICS LTD. (GB) | 2010-10-21 | — | — | US | disclosed |
| US-20100267774-A1 | P38 MAP KINASE INHIBITORS | CHROMA THERAPEUTICS LTD. (GB) | 2010-10-21 | — | — | US | disclosed |
| EP-2220044-A1 | P38 MAP KINASE INHIBITORS | Chroma Therapeutics Limited (GB) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009060160-A1 | P38 MAP KINASE INHIBITORS | CHROMA THERAPEUTICS LTD. (GB) | 2009-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267774-A1 | P38 MAP KINASE INHIBITORS | MAPK1, MAPK3, MAPK12 | MAPT 3486/4885HTT 4647/4885KDM4E 4147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.