Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.54 |
| ▸ | RAF1 | P04049 | 1/20 | 0.54 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.54 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.52 |
| ▸ | TUBB | P07437 | 2/20 | 0.52 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.52 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2125898 | 0.85 | MAPK1 (0.53) | MAPK13RAF1MAPK12MAPK11MAPK14 | |
| SCHEMBL2125895 | 0.85 | MAPK1 (0.53) | MAPK13RAF1MAPK12MAPK11MAPK14 | |
| SCHEMBL1481326 | 0.83 | RELA (0.49) | MAPTTP53MAPK13RAF1MAPK12 | |
| SCHEMBL1481328 | 0.83 | RELA (0.49) | MAPTTP53MAPK13RAF1MAPK12 | |
| SCHEMBL6468773 | 0.79 | MAPK13 (0.59) | MAPK13RAF1MAPK12MAPK11MAPK14 | |
| SCHEMBL6468772 | 0.79 | MAPK13 (0.59) | MAPK13RAF1MAPK12MAPK11MAPK14 | |
| SCHEMBL7088168 | 0.78 | PTGS2 (0.64) | ALDH1A1HPGD | |
| SCHEMBL8104080 | 0.76 | MAPK13 (0.86) | MAPTTP53MAPK13RAF1MAPK12 | |
| SCHEMBL1308320 | 0.76 | MAPK13 (0.86) | MAPTTP53MAPK13RAF1MAPK12 | |
| SCHEMBL15400046 | 0.76 | MAPK13 (0.86) | MAPTTP53MAPK13RAF1MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240000821-A1 | CHEMICAL INHIBITORS AGAINST KINASES TO BLOCK TELOMERE ELONGATION IN CANCER | UNIV JOHNS HOPKINS (US) | 2024-01-04 | — | — | US | disclosed |