Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.46 |
| ▸ | GRM8 | O00222 | 1/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.39 |
| ▸ | CDK9 | P50750 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30713687 | 0.82 | LRRK2 (0.50) | GPR84GRM8GRM4LRRK2AXL | |
| SCHEMBL27764321 | 0.81 | GPR84 (0.50) | GPR84GRM8GRM4LRRK2AXL | |
| SCHEMBL14665063 | 0.81 | GPR84 (0.50) | GPR84GRM8GRM4LRRK2AXL | |
| SCHEMBL857209 | 0.78 | MET (0.56) | GPR84GRM8GRM4LRRK2AXL | |
| SCHEMBL27500637 | 0.78 | GRM8 (0.48) | GPR84GRM8GRM4LRRK2AXL | |
| SCHEMBL27524118 | 0.78 | GRM8 (0.48) | GPR84GRM8GRM4LRRK2AXL | |
| SCHEMBL30713640 | 0.78 | GPR84 (0.55) | GPR84LRRK2AXLMETKMT2A | |
| SCHEMBL12491066 | 0.75 | AXL (0.51) | GPR84GRM8GRM4LRRK2AXL | |
| SCHEMBL858688 | 0.75 | MET (0.52) | GPR84GRM8GRM4AXLMET | |
| SCHEMBL31358333 | 0.74 | GPR84 (0.43) | GPR84GRM8GRM4LRRK2AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117295746-A | HPK1 inhibitor and application thereof in medicine | 贝达药业股份有限公司 | 2023-12-26 | — | — | CN | disclosed |