Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phthalazinone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 known ✓ | P09874 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.62 |
| ▸ | PRKCI | P41743 | 1/20 | 0.62 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phthalazinone SCHEMBL30718073 | 0.89 | PARP1 (0.70) | ALDH1A1TDP1PARP1PRKCIPDE4B | |
| Phthalazinone SCHEMBL30718074 | 0.84 | PARP1 (0.77) | ALDH1A1TDP1PARP1PRKCIPDE4B | |
| Phthalazinone SCHEMBL28666564 | 0.84 | PARP1 (0.82) | ALDH1A1TDP1PARP1PRKCIPDE4B | |
| Phthalazinone SCHEMBL11516881 | 0.81 | PARP1 (0.96) | ALDH1A1TDP1PARP1PRKCIPDE4B | |
| Phthalazinone SCHEMBL51553 | 0.79 | PARP1 (1.00) | ALDH1A1TDP1PARP1PRKCIPDE4B | |
| Phthalazinone SCHEMBL23087695 | 0.77 | HSD17B10 (0.89) | ALDH1A1TDP1PARP1PRKCIPDE4B | |
| Phthalazinone SCHEMBL27172629 | 0.77 | PARP1 (0.89) | ALDH1A1TDP1PARP1PRKCIPDE4B | |
| Phthalazinone SCHEMBL11516875 | 0.77 | PARP1 (0.96) | ALDH1A1TDP1PARP1PRKCIPDE4B | |
| Phthalazinone SCHEMBL2473799 | 0.77 | PARP1 (0.96) | ALDH1A1TDP1PARP1PRKCIPDE4B | |
| Phthalazinone SCHEMBL2962226 | 0.77 | PARP1 (0.96) | ALDH1A1TDP1PARP1PRKCIPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117321044-A | Poly (ADP-ribose) polymerase inhibitors | 理森制药股份公司 | 2023-12-29 | — | — | CN | claimed |