Known targets — ChEMBL curated mechanism
BTKCACNA1CCACNA1DCACNA1FCACNA1SCACNA2D1CACNA2D2DRD2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQHRH1HTR2AP2RY12
The experimentally established mechanism targets of Phthalazinone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.70 |
| ▸ | PRKCI | P41743 | 1/20 | 0.70 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phthalazinone SCHEMBL28666564 | 0.89 | PARP1 (0.82) | PARP1ALDH1A1HSD17B10TDP1PRKCI | |
| Phthalazinone SCHEMBL30718072 | 0.89 | ALDH1A1 (0.62) | PARP1ALDH1A1HSD17B10TDP1PRKCI | |
| Phthalazinone SCHEMBL30718074 | 0.86 | PARP1 (0.77) | PARP1ALDH1A1HSD17B10TDP1PRKCI | |
| Phthalazinone SCHEMBL27602022 | 0.85 | PARP1 (0.96) | PARP1ALDH1A1HSD17B10TDP1PRKCI | |
| Phthalazinone SCHEMBL11516881 | 0.85 | PARP1 (0.96) | PARP1ALDH1A1HSD17B10TDP1PRKCI | |
| Phthalazinone SCHEMBL51553 | 0.83 | PARP1 (1.00) | PARP1ALDH1A1HSD17B10TDP1PRKCI | |
| Phthalazinone SCHEMBL27172629 | 0.82 | PARP1 (0.89) | PARP1ALDH1A1HSD17B10TDP1PRKCI | |
| Phthalazinone SCHEMBL11519244 | 0.82 | PARP1 (0.96) | PARP1ALDH1A1HSD17B10TDP1PRKCI | |
| Phthalazinone SCHEMBL11690359 | 0.82 | PARP1 (0.96) | PARP1ALDH1A1HSD17B10TDP1PRKCI | |
| Phthalazinone SCHEMBL11519239 | 0.82 | PARP1 (0.96) | PARP1ALDH1A1HSD17B10TDP1PRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117321044-A | Poly (ADP-ribose) polymerase inhibitors | 理森制药股份公司 | 2023-12-29 | — | — | CN | claimed |