Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.53 |
| ▸ | DKK1 | O94907 | 2/20 | 0.49 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | MYLK4 | Q86YV6 | 3/20 | 0.45 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 3/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27029440 | 1.00 | CHRNB2 (0.53) | CHRNB2CHRNA4DKK1NISCHADRB1 | |
| SCHEMBL27063740 | 0.95 | CHRNB2 (0.61) | CHRNB2CHRNA4DKK1NISCHADRB1 | |
| SCHEMBL29931680 | 0.87 | DKK1 (0.51) | CHRNB2CHRNA4DKK1NISCHPIK3CA | |
| SCHEMBL27029515 | 0.85 | HTR3A (0.58) | DKK1STK17AACHEPIK3CAKDM4E | |
| SCHEMBL30718191 | 0.85 | HTR3A (0.58) | DKK1STK17AACHEPIK3CAKDM4E | |
| SCHEMBL29931584 | 0.84 | DKK1 (0.51) | CHRNB2CHRNA4DKK1NISCHPIK3CA | |
| SCHEMBL3652486 | 0.83 | DKK1 (0.69) | DKK1ADRB1MYLK4STK17AACHE | |
| SCHEMBL27029497 | 0.83 | DKK1 (0.72) | DKK1PIK3CAPIK3CDPIK3R1PIK3CB | |
| SCHEMBL30718212 | 0.83 | CHRNB2 (0.51) | CHRNB2CHRNA4NISCHADRB1PIK3CA | |
| SCHEMBL27029561 | 0.83 | CHRNB2 (0.51) | CHRNB2CHRNA4NISCHADRB1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117157284-A | CTLA-4 small molecule degradation agent and application thereof | 苏州国匡医药科技有限公司 | 2023-12-01 | — | — | CN | disclosed |