Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 3/20 | 0.58 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.56 |
| ▸ | DKK1 | O94907 | 2/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27029515 | 1.00 | HTR3A (0.58) | HTR3AHRH4DKK1CCNT1CCNA2 | |
| SCHEMBL29931680 | 0.87 | DKK1 (0.51) | DKK1CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL27029440 | 0.85 | CHRNB2 (0.53) | DKK1PIK3CAKDM4ESTK17AACHE | |
| SCHEMBL30718239 | 0.85 | CHRNB2 (0.53) | DKK1PIK3CAKDM4ESTK17AACHE | |
| SCHEMBL29931584 | 0.84 | DKK1 (0.51) | HTR3ADKK1PIK3CA | |
| SCHEMBL29931574 | 0.83 | HCAR2 (0.50) | DKK1MTORKDM4ENPC1RAB9A | |
| SCHEMBL3651842 | 0.83 | DKK1 (0.69) | HTR3AHRH4DKK1CCNT1CCNA2 | |
| SCHEMBL27029497 | 0.83 | DKK1 (0.72) | DKK1PIK3CAMTOR | |
| SCHEMBL29115940 | 0.82 | DKK1 (0.53) | HTR3AHRH4DKK1PIK3CAMTOR | |
| SCHEMBL1275203 | 0.81 | SORD (0.61) | HRH4CCNT1CCNA2CDK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117157284-A | CTLA-4 small molecule degradation agent and application thereof | 苏州国匡医药科技有限公司 | 2023-12-01 | — | — | CN | disclosed |