SCHEMBL30719728

SCHEMBL30719728

Cc1oc2cnc(OCc3ccccc3F)cc2c1C(=O)NC1(CO)CC1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC26A4 O43511 2/20 0.38
GABRA1 P14867 1/20 0.37
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
GCK P35557 2/20 0.35
RARA P10276 1/20 0.35
RARB P10826 1/20 0.35
RARG P13631 1/20 0.35
SCN9A Q15858 1/20 0.35
CD274 Q9NZQ7 1/20 0.35
RET P07949 1/20 0.34
ROCK2 O75116 1/20 0.34
LRRK2 Q5S007 1/20 0.34
RXFP1 Q9HBX9 1/20 0.33
GABRA5 P31644 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
NR3C1 P04150 1/20 0.33
GUCY1B2 O75343 1/20 0.33
GUCY1A2 P33402 1/20 0.33
GUCY1A1 Q02108 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26877794 1.00 SLC26A4 (0.38) SLC26A4GABRA1MEN1KMT2AGCK
SCHEMBL24470582 0.86 SLC26A4 (0.55) SLC26A4MEN1KMT2ALMNAMAPT
SCHEMBL29713015 0.86 SLC26A4 (0.55) SLC26A4MEN1KMT2ALMNAMAPT
SCHEMBL30719742 0.85 GABRA1 (0.37) SLC26A4GABRA1MEN1KMT2ASCN9A
SCHEMBL30719751 0.85 L3MBTL1 (0.39) GABRA1SCN9AGABRA5TSHR
SCHEMBL26699045 0.82 CASP3 (0.43) SLC26A4GABRA1MEN1KMT2AGABRA5
SCHEMBL24470745 0.82 SLC26A4 (0.53) SLC26A4MEN1KMT2ALMNAMAPT
SCHEMBL29712967 0.82 SLC26A4 (0.53) SLC26A4MEN1KMT2ALMNAMAPT
SCHEMBL30719886 0.82 CASP3 (0.43) SLC26A4GABRA1MEN1KMT2AGABRA5
SCHEMBL30719910 0.82 SLC26A4 (0.55) SLC26A4MEN1KMT2AGCKRARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4532011-A1 NEW DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS Katholieke Universiteit Leuven KU Leuven Research & Development (BE) 2025-04-09 EP claimed
CN-119421883-A Novel derivatives for the treatment of TRPM3 mediated disorders 勒芬天主教大学 2025-02-11 CN claimed
WO-2023227698-A1 NEW DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2023-11-30 WO claimed
EP-4532011-A1 NEW DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS Katholieke Universiteit Leuven KU Leuven Research & Development (BE) 2025-04-09 EP disclosed
CN-119421883-A Novel derivatives for the treatment of TRPM3 mediated disorders 勒芬天主教大学 2025-02-11 CN disclosed
WO-2023227698-A1 NEW DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2023-11-30 WO disclosed