Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2E1 | P05181 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | TAF1 | P21675 | 1/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9405397 | 0.74 | NPC1 (0.49) | CYP2E1CYP3A4CYP2A6ALDH1A1BDKRB2 | |
| SCHEMBL16719842 | 0.70 | AHR (0.48) | AHRALDH1A1BRD4TAF1BRPF1 | |
| SCHEMBL14428964 | 0.70 | CYP3A4 (0.50) | CYP2E1CYP3A4CYP2A6ALDH1A1KDM4E | |
| SCHEMBL31399832 | 0.68 | HTR6 (0.39) | CYP2E1CYP3A4CYP2A6ALDH1A1NR3C1 | |
| SCHEMBL21128560 | 0.68 | FLT1 (0.44) | CYP2E1CYP3A4CYP2A6ALDH1A1 | |
| SCHEMBL6258693 | 0.67 | CYP3A4 (0.47) | CYP2E1CYP3A4CYP2A6ALDH1A1KEAP1 | |
| SCHEMBL19029697 | 0.67 | CYP3A4 (0.47) | CYP2E1CYP3A4CYP2A6ALDH1A1ADH5 | |
| SCHEMBL28183364 | 0.67 | CYP3A4 (0.47) | CYP2E1CYP3A4CYP2A6PIK3CAMTOR | |
| SCHEMBL12342913 | 0.67 | CYP3A4 (0.47) | CYP2E1CYP3A4CYP2A6ALDH1A1GRM5 | |
| SCHEMBL28144636 | 0.67 | CYP3A4 (0.47) | CYP2E1CYP3A4CYP2A6ALDH1A1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4562004-A1 | NOVEL 7-SUBSTITUTED INDOLE SULFONAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2025-06-04 | — | — | EP | disclosed |
| CN-119585258-A | Novel 7-substituted indole sulfonamide derivatives | 豪夫迈·罗氏有限公司 | 2025-03-07 | — | — | CN | disclosed |
| WO-2024023129-A1 | NOVEL 7-SUBSTITUTED INDOLE SULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2024-02-01 | — | — | WO | disclosed |