Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 2/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | TAF1 | P21675 | 1/20 | 0.39 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.39 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 4/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28840823 | 0.72 | TLR9 (0.50) | AHRKEAP1PDPK1BRD4TAF1 | |
| SCHEMBL3297385 | 0.71 | HTR6 (0.57) | ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL28654673 | 0.71 | AHR (0.43) | AHRKEAP1PDPK1BRD4TAF1 | |
| SCHEMBL30215970 | 0.70 | AHR (0.39) | AHRKEAP1PDPK1BRD4TAF1 | |
| SCHEMBL30721404 | 0.70 | CYP2E1 (0.41) | AHRKEAP1PDPK1ALDH1A1BRD4 | |
| SCHEMBL7229298 | 0.69 | AHR (0.42) | AHRKEAP1PDPK1BRD4TAF1 | |
| SCHEMBL31049275 | 0.69 | BCHE (0.51) | AHRALDH1A1MAPTKDM4EGAA | |
| SCHEMBL18000216 | 0.69 | BCHE (0.51) | AHRALDH1A1MAPTKDM4EGAA | |
| SCHEMBL16720217 | 0.69 | NOS1 (0.52) | ALDH1A1MAPTKDM4EGAAPARP1 | |
| SCHEMBL31492457 | 0.69 | AHR (0.60) | AHRKEAP1PDPK1BRD4NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |