SCHEMBL30723922

SCHEMBL30723922

COc1ccc2c(c1)CCCC(Br)=C2c1c(F)cc(OCc2ccccc2)cc1F

nearest known ligand 0.50

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MAOB P27338 14/20 0.50
MAOA P21397 13/20 0.50
ESR1 P03372 3/20 0.45
CYP27A1 Q02318 1/20 0.41
CYP24A1 Q07973 1/20 0.41
ALDH1A1 P00352 1/20 0.40
MAPT P10636 1/20 0.40
KMT2A Q03164 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
HRH3 Q9Y5N1 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30769016 0.94 MAOB (0.44) MAOBMAOAESR1CYP27A1CYP24A1
SCHEMBL30724068 0.87 ESR1 (0.60) MAOBMAOAESR1
SCHEMBL5852029 0.83 MAOB (0.57) MAOBMAOAESR1MAPTHRH3
SCHEMBL30769201 0.82 EBP (0.52) MAOBMAOAESR1CYP24A1HRH3
SCHEMBL30723754 0.80 MAOB (0.48) MAOBMAOAESR1CYP24A1ALDH1A1
SCHEMBL30768559 0.79 MAOB (0.41) MAOBMAOAESR1CYP24A1HRH3
SCHEMBL23297257 0.78 EBP (0.51) MAOBMAOAESR1CYP27A1MAPT
SCHEMBL30769328 0.78 MPO (0.46) MAOBMAOACYP24A1ALDH1A1HRH3
SCHEMBL30769413 0.74 MAOB (0.48) MAOBMAOACYP24A1HRH3
SCHEMBL5852025 0.72 ESR1 (0.72) MAOBMAOAESR1MAPTHRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024006776-A1 ESTROGEN RECEPTOR ALPHA DEGRADERS AND MEDICAL USE THEREOF RELAY THERAPEUTICS, INC. (US) 2024-01-04 WO disclosed